1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone

Base Information

Chemical Name:1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone
CAS No.:2221-76-3
Molecular Formula:C₁₄H₂₀O
Molecular Weight:204.312
Hs Code.:
Mol file:2221-76-3.mol

Synonyms:1'-Acetonaphthone,1',2',3',4',4'a,5',6',8'a-octahydro-7'-methyl-4'-methylene- (8CI);1'-Acetonaphthone, 1'a,2',3',4',4'aa,5',6',8'ab-octahydro-7'-methyl-4'-methylene-(7CI); Ethanone,1-(1,2,3,4,4a,5,6,8a-octahydro-7-methyl-4-methylene-1-naphthalenyl)-, [1S-(1a,4ab,8aa)]-; Khusitone

Suppliers and Price of 1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone

Chemical Property:

PSA：17.07000
LogP:3.51410

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone

There total 18 articles about 1-(1,2,3,4,4a,5,6,8a-Octahydro-7-methyl-4-methylenenaphthalen-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121666-50-0
4-acetylhex-3-enone 1-ethylene ketal

: 2221-76-3,121703-16-0
(+/-)-khusitone

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) LDA / 1.) THF, -85 deg C, 30 min, 2.) 1 h

2: 11.9 percent / TiCl₂(OPr-i)2 / CH₂Cl₂ / 3.5 h / -85 - -18 °C

3: 64 percent / NaH / methanol / 10.5 h / Ambient temperature

4: 45 percent / tetrahydrofuran / 5 h

5: LiAlH₄ / diethyl ether / 15 h

6: 71 percent / PTSA monohydrate / acetone; H₂O / 1.5 h / Heating

7: 51 percent / diethyl ether / 1.) ice-bath, 2 h, 2.) room temperature, 1.5 h

8: 63 percent / Jones' reagent / acetone

9: POCl₃ / pyridine / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; jones' reagent; titanium(IV) dichlorodiisopropylate; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; acetone;

Reference yield:

: 115367-26-5
4-acetyl-3,4,4a,7,8,8a-hexahydro-4-(trimethylsilyl)naphthalene-1,6(2H,5H)-dione 6-ethylene ketal

: 2221-76-3,121703-16-0
(+/-)-khusitone

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / NaH / methanol / 10.5 h / Ambient temperature

2: 45 percent / tetrahydrofuran / 5 h

3: LiAlH₄ / diethyl ether / 15 h

4: 71 percent / PTSA monohydrate / acetone; H₂O / 1.5 h / Heating

5: 51 percent / diethyl ether / 1.) ice-bath, 2 h, 2.) room temperature, 1.5 h

6: 63 percent / Jones' reagent / acetone

7: POCl₃ / pyridine / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; jones' reagent; sodium hydride; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; diethyl ether; water; acetone;

Reference yield:

: 121666-51-1
4-<1-(trimethylsiloxy)vinyl>cyclohex-3-enone 1-ethylene ketal

: 2221-76-3,121703-16-0
(+/-)-khusitone

Guidance literature:: Multi-step reaction with 9 steps

1: 17 percent / TiCl₂(OPr-i)2 / CH₂Cl₂ / 3.5 h / -85 - -18 °C

2: 1.) LDA / 1.) THF, -85 deg C, 30 min, 2.) -85 deg C -> room temperature, overnight

3: 64 percent / NaH / methanol / 10.5 h / Ambient temperature

4: 45 percent / tetrahydrofuran / 5 h

5: LiAlH₄ / diethyl ether / 15 h

6: 71 percent / PTSA monohydrate / acetone; H₂O / 1.5 h / Heating

7: 51 percent / diethyl ether / 1.) ice-bath, 2 h, 2.) room temperature, 1.5 h

8: 63 percent / Jones' reagent / acetone

9: POCl₃ / pyridine / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; jones' reagent; titanium(IV) dichlorodiisopropylate; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; acetone;