4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-

Base Information

Chemical Name:4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-
CAS No.:117560-10-8
Molecular Formula:C17H21 N3 O6
Molecular Weight:363.37
Hs Code.:

Synonyms:4-Imidazolidinecarboxylicacid, 3-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-2-oxo-,[4S-[3[R*(R*)],4R*]]-; 6366DM

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Chemical Property of 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-

There total 11 articles about 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117560-18-6
(S)-3-[(S)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester; compound with (Z)-but-2-enedioic acid

: 117560-10-8
(S)-3-[(S)-2-((S)-1-Carboxy-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-4-carboxylic acid

Guidance literature:: With hydrogen; palladium; In methanol; for 2h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00122a003

Reference yield:

: 16503-46-1
2-bromo-4-phenyl butanoic acid

: 117560-10-8
(S)-3-[(S)-2-((S)-1-Carboxy-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 28percent aq. NH₃ / 168 h / Ambient temperature

3: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

4: benzene / 6 h / Heating

5: 40.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

6: ethyl acetate; diisopropyl ether

7: 94 percent / 15percent HCl/dioxane / Ambient temperature

8: DCC / tetrahydrofuran / Ambient temperature

9: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min

10: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature

11: H₂ / Pd / methanol / 2 h / 760 Torr / Ambient temperature

With hydrogenchloride; ammonium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1021/jm00122a003

Reference yield:

: 1012-05-1
D,L-homophenylalanine

: 117560-10-8
(S)-3-[(S)-2-((S)-1-Carboxy-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

2: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

3: benzene / 6 h / Heating

4: 40.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

5: ethyl acetate; diisopropyl ether

6: 94 percent / 15percent HCl/dioxane / Ambient temperature

7: DCC / tetrahydrofuran / Ambient temperature

8: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min

9: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature

10: H₂ / Pd / methanol / 2 h / 760 Torr / Ambient temperature

With hydrogenchloride; potassium tert-butylate; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1021/jm00122a003