(2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid

Base Information

• Chemical Name: (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid
• CAS No.: 71603-06-0
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.201
• DSSTox Substance ID: DTXSID601222394
• Nikkaji Number: J3.209.142C
• Mol file: 71603-06-0.mol

Synonyms:71603-06-0;(2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid;(Z)-4-((4-aminophenyl)amino)-4-oxobut-2-enoic Acid;2-Butenoic acid, 4-[(4-aminophenyl)amino]-4-oxo-, (Z)-;starbld0047406;(2Z)-3-[(4-AMINOPHENYL)CARBAMOYL]PROP-2-ENOIC ACID;SCHEMBL4839638;N-(p-amino-phenyl)maleamic acid;TYNXYWZQXWAHRJ-WAYWQWQTSA-N;DTXSID601222394;AKOS002819377;SS-5162;(Z)-4-(4-aminoanilino)-4-oxobut-2-enoic acid;(z)-4-((4-aminophenyl)amino)-4-oxobut-2-enoicacid

Chemical Property of (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid

Chemical Property:

• XLogP3: 0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 206.06914219
• Heavy Atom Count: 15
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)NC(=O)C=CC(=O)O
• Isomeric SMILES: C1=CC(=CC=C1N)NC(=O)/C=C\C(=O)O

Technology Process of (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid

There total 1 articles about (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

maleic anhydride (108-31-6) + 1,4-phenylenediamine (106-50-3) → (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid (71603-06-0)

Guidance literature:

at 20 ℃; for 2h;

DOI:10.1081/SCC-200066665

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid (71603-06-0) → (2Z)-4-[(4-tert-butoxycarbonylaminophenyl)amino]-4-oxo-2-butenoic acid

Guidance literature:

(2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid; With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃;

di-tert-butyl dicarbonate; at 20 ℃; for 0.75h;

Reference yield: 85.0%

acetic anhydride (108-24-7) + (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid (71603-06-0) → N-(4-acetylamidophenyl)maleimide (5702-75-0)

Guidance literature:

With sodium acetate; for 1h;

upstream raw materials:

maleic anhydride

1,4-phenylenediamine

Downstream raw materials:

1‐(4‐aminophenyl)‐1H‐pyrrole‐2,5‐dione

N-(4-acetylamidophenyl)maleimide

N-(4-isothiocyanatophenyl)maleimide

N-(4-bromoacetamidophenyl)maleimide