Benzenemethanamine, 4,5-dimethoxy-a-[[[(4-methylphenyl)methyl]thio]methyl]-2-nitro-

Base Information

Chemical Name:Benzenemethanamine, 4,5-dimethoxy-a-[[[(4-methylphenyl)methyl]thio]methyl]-2-nitro-
CAS No.:716345-99-2
Molecular Formula:C₁₈H₂₂N₂O₄S
Molecular Weight:362.45
Hs Code.:

Synonyms:

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Chemical Property of Benzenemethanamine, 4,5-dimethoxy-a-[[[(4-methylphenyl)methyl]thio]methyl]-2-nitro-

Chemical Property:

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Technology Process of Benzenemethanamine, 4,5-dimethoxy-a-[[[(4-methylphenyl)methyl]thio]methyl]-2-nitro-

There total 5 articles about Benzenemethanamine, 4,5-dimethoxy-a-[[[(4-methylphenyl)methyl]thio]methyl]-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20357-25-9
6-nitroveratraldehyde

: 716345-99-2
1-(4,5-dimethoxy-2-nitro-phenyl)-2-(4-methyl-benzylsulfanyl)-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazide / tetrahydrofuran / 1 h

1.2: 65 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 53 percent / tert-butyl hypochlorite; sodium hydroxide; (DHQ)2PHAL / K₂OsO₂(OH)4 / propan-1-ol; H₂O / 45 h / 4 °C

3.1: 98 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C

4.1: sodium methoxide / ethanol; methanol / 0.08 h

4.2: 97 percent / ethanol; methanol / 0.33 h

5.1: TFA / 0.08 h

With sodium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; di-isopropyl azodicarboxylate; sodium methylate; sodium hexamethyldisilazane; triphenylphosphine; trifluoroacetic acid; potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; methanol; propan-1-ol; ethanol; water; 2.1: Sharpless aminohydroxylation / 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.02.039

Reference yield:

: 65907-71-3
1,2-dimethoxy-4-nitro-5-vinylbenzene

: 716345-99-2
1-(4,5-dimethoxy-2-nitro-phenyl)-2-(4-methyl-benzylsulfanyl)-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 53 percent / tert-butyl hypochlorite; sodium hydroxide; (DHQ)2PHAL / K₂OsO₂(OH)4 / propan-1-ol; H₂O / 45 h / 4 °C

2.1: 98 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C

3.1: sodium methoxide / ethanol; methanol / 0.08 h

3.2: 97 percent / ethanol; methanol / 0.33 h

4.1: TFA / 0.08 h

With sodium hydroxide; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; di-isopropyl azodicarboxylate; sodium methylate; triphenylphosphine; trifluoroacetic acid; potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; methanol; propan-1-ol; ethanol; water; 1.1: Sharpless aminohydroxylation / 2.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.02.039

Reference yield:

: 716345-93-6
[1-(4,5-dimethoxy-2-nitro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 716345-99-2
1-(4,5-dimethoxy-2-nitro-phenyl)-2-(4-methyl-benzylsulfanyl)-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C

2.1: sodium methoxide / ethanol; methanol / 0.08 h

2.2: 97 percent / ethanol; methanol / 0.33 h

3.1: TFA / 0.08 h

With di-isopropyl azodicarboxylate; sodium methylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.02.039