Tetrabenazine

Base Information

Chemical Name:Tetrabenazine
CAS No.:718635-93-9
Molecular Formula:C19H27NO3
Molecular Weight:317.42300
Hs Code.:
European Community (EC) Number:200-383-6,823-306-3
NSC Number:172187,169886
DSSTox Substance ID:DTXSID501127442
Nikkaji Number:J4.592F
Wikipedia:Tetrabenazine,Deutetrabenazine
Wikidata:Q413050
NCI Thesaurus Code:C174828,C81095
RXCUI:10390,1876905
Pharos Ligand ID:44CKHNGWGQZG,44CY1JWAXBS3
Metabolomics Workbench ID:149275
ChEMBL ID:CHEMBL117785
Mol file:718635-93-9.mol

Synonyms:Nitoman;Tetrabenazine;Xenazine

Suppliers and Price of Tetrabenazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tetrabenazine
5mg
$ 75.00

Crysdot
TetrabenazineRacemate 95+%
250mg
$ 358.00

Crysdot
TetrabenazineRacemate 95+%
100mg
$ 247.00

ChemScene
Tetrabenazine(Racemate) >98.0%
25mg
$ 100.00

ChemScene
Tetrabenazine(Racemate) >98.0%
100mg
$ 200.00

ChemScene
Tetrabenazine(Racemate) >98.0%
50mg
$ 150.00

Ambeed
TetrabenazineRacemate 95+%
1g
$ 496.00

Ambeed
TetrabenazineRacemate 95+%
100mg
$ 136.00

Ambeed
TetrabenazineRacemate 95+%
250mg
$ 198.00

Ambeed
TetrabenazineRacemate 95+%
50mg
$ 85.00

Total 13 raw suppliers

Chemical Property of Tetrabenazine

Chemical Property:

Melting Point:125 °C
Boiling Point:448.9±45.0 °C(Predicted)
PKA:6.46±0.40(Predicted)
PSA：38.77000
Density:1.12±0.1 g/cm3(Predicted)
LogP:3.17600
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:317.19909372
Heavy Atom Count:23
Complexity:425

Purity/Quality:

99.9% ^*data from raw suppliers

Tetrabenazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Recent ClinicalTrials:Compassionate Use of Tetrabenazine in the Treatment of Abnormal Movements
Recent EU Clinical Trials:An Open-Label, Long-Term Safety, Tolerability, and Efficacy Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents (Open RECLAIM-DCP)
Uses Tetrabenazine is a dopamine depleting medication for the treatment of chorea in Huntington’s disease.

Technology Process of Tetrabenazine

There total 18 articles about Tetrabenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 3-[(dimethylamino)-methyl]-5-methylhexan-2-one oxalate

: 20232-39-7
3,4-dihydro-6,7-dimethoxyisoquinoline hydrochloride

: 718635-93-9,1381929-92-5
tetrabenazine

Guidance literature:: 3-[(dimethylamino)-methyl]-5-methylhexan-2-one oxalate; With potassium hydroxide; In tert-butyl methyl ether; water; at 22 ℃; for 0.25h; pH=11; Large scale;

3,4-dihydro-6,7-dimethoxyisoquinoline hydrochloride; With sodium iodide; In water; isopropyl alcohol; at 22 - 42 ℃; for 25h; Large scale;