(2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Base Information

Chemical Name:(2S)-1-benzyloxycarbonyl-4,4-difluoroproline
CAS No.:72180-27-9
Molecular Formula:C13H13F2NO4
Molecular Weight:285.247
Hs Code.:
DSSTox Substance ID:DTXSID501174893

Synonyms:72180-27-9;(2S)-1-benzyloxycarbonyl-4,4-difluoroproline;(S)-1-((Benzyloxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid;1,2-Pyrrolidinedicarboxylic acid, 4,4-difluoro-, 1-(phenylmethyl) ester, (2S)-;(2S)-1-((BENZYLOXY)CARBONYL)-4,4-DIFLUOROPYRROLIDINE-2-CARBOXYLIC ACID;(2S)-1-[(BENZYLOXY)CARBONYL]-4,4-DIFLUOROPYRROLIDINE-2-CARBOXYLIC ACID;SCHEMBL703547;DTXSID501174893;AKOS026739632;AT28739;N-carbobenzyloxy-4,4-difluoro-L-proline;N-carbobenzyloxy-4, 4-difluoro-L-proline;1-[(benzyloxy)carbonyl]4,4-difluoro-L-proline;1-[(Benzyloxy)carbonyl]-4,4-difluoro-L-proline;EN300-6305738;(S)-4,4-difluoro-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester;1-(Phenylmethyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate

Suppliers and Price of (2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:285.08126422
Heavy Atom Count:20
Complexity:383

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(N(CC1(F)F)C(=O)OCC2=CC=CC=C2)C(=O)O
Isomeric SMILES:C1[C@H](N(CC1(F)F)C(=O)OCC2=CC=CC=C2)C(=O)O

Technology Process of (2S)-1-benzyloxycarbonyl-4,4-difluoroproline

There total 3 articles about (2S)-1-benzyloxycarbonyl-4,4-difluoroproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38078-09-0
diethylamino-sulfur trifluoride

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 72180-27-9
(2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Guidance literature:: In dichloromethane;

Reference yield:

: 16217-15-5
1-benzyloxycarbonyl-4-oxo-L-proline methyl ester

: 72180-27-9
(2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 12 h / 0 - 15 °C

2: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 15 °C

With lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: N-Cbz-cis-4-hydroxyl-L-methyl prolinate

: 72180-27-9
(2S)-1-benzyloxycarbonyl-4,4-difluoroproline

Guidance literature:: Multi-step reaction with 3 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 15 °C

2: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 12 h / 0 - 15 °C

3: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 15 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; In tetrahydrofuran; ethanol; dichloromethane;