Technology Process of 1-Oxa-4-azacyclotridec-9-ene-2,5-dione,
13-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,6,8,11-tetramethyl-3-(
phenylmethyl)-, (3S,6R,8S,9Z,11S,13R)-
There total 12 articles about 1-Oxa-4-azacyclotridec-9-ene-2,5-dione,
13-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,6,8,11-tetramethyl-3-(
phenylmethyl)-, (3S,6R,8S,9Z,11S,13R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
Heating;
DOI:10.1021/ol061029w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminum hydride / diethyl ether / 6 h / 0 - 20 °C
1.2: 67 percent / TBAF / tetrahydrofuran / 2 h / 20 °C
2.1: 72 percent / Jones' reagent / acetone / 2.5 h / 0 - 20 °C
3.1: 141 mg / HOBt; EDCI / CH2Cl2 / 6 h / 20 °C
4.1: 93 percent / Grubb's catalyst 2nd generation / CH2Cl2 / Heating
With
lithium aluminium tetrahydride; jones' reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
diethyl ether; dichloromethane; acetone;
DOI:10.1021/ol061029w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 289 mg / n-BuLi / tetrahydrofuran; hexane / 3 h / 20 °C
2: 67 percent / triphenylphosphine; DIAD / diethyl ether / 1.5 h / 20 °C
3: TFA / CH2Cl2 / 1 h / 0 °C
4: 141 mg / HOBt; EDCI / CH2Cl2 / 6 h / 20 °C
5: 93 percent / Grubb's catalyst 2nd generation / CH2Cl2 / Heating
With
n-butyllithium; di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
1: Wittig reaction / 2: Mitsunobu reaction;
DOI:10.1021/ol061029w