4-HYDROXYMETHYL-7-METHOXYCOUMARIN

Base Information

• Chemical Name: 4-HYDROXYMETHYL-7-METHOXYCOUMARIN
• CAS No.: 72433-26-2
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Mol file: 72433-26-2.mol

Synonyms:4-Hydroxymethyl-7-methoxy-cumarin;6-methoxy-1-hydroxymethyl-3-oxo-3H-benzopyran;4-(hydroxymethyl)-7-methoxycoumarin;4-(Hydroxymethyl)-7-methoxy-2H-chromen-2-one;7-methoxycoumarin-4-ylmethanol;

Chemical Property of 4-HYDROXYMETHYL-7-METHOXYCOUMARIN

Chemical Property:

• PSA: 59.67000
• LogP: 1.29390

Purity/Quality:

99% ^*data from raw suppliers

4-(Hydroxymethyl)-7-methoxy-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYMETHYL-7-METHOXYCOUMARIN

There total 16 articles about 4-HYDROXYMETHYL-7-METHOXYCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7-methoxycoumarin-4-yl)methyl-4-methoxybenzoate (76196-60-6) → 6-methoxy-1-hydroxymethyl-3-oxo-3H-benzopyran (72433-26-2) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

With HEPES buffer; In water; acetonitrile; Quantum yield; UV-irradiation;

DOI:10.1021/jo9910233

Reference yield:

(7-methoxycoumarin-4-yl)methyl-4-cyanobenzoate → 4-cyanobenzoic Acid (619-65-8,333406-09-0) + 6-methoxy-1-hydroxymethyl-3-oxo-3H-benzopyran (72433-26-2)

Guidance literature:

With HEPES buffer; In water; acetonitrile; Quantum yield; UV-irradiation;

DOI:10.1021/jo9910233

Reference yield:

diethyl (7'-methoxy-2'-oxobenzopyran-4'-yl)methyl phosphate (92543-28-7) → Diethyl phosphate (598-02-7) + 6-methoxy-1-hydroxymethyl-3-oxo-3H-benzopyran (72433-26-2)

Guidance literature:

With HEPES buffer; In water; acetonitrile; Quantum yield; UV-irradiation;

DOI:10.1021/jo9910233

upstream raw materials:

(7-methoxycoumarin-4-yl)methyl-4-methoxybenzoate

(7-methoxycoumarin-4-yl)methylbenzoate

(7-methoxycoumarin-4-yl)methylmethanesulfonate

diethyl (7'-methoxy-2'-oxobenzopyran-4'-yl)methyl phosphate

Downstream raw materials:

4-(chloromethyl)-7-methoxy-2H-chromen-2-one

2-(tert-butyloxycarbonylamino)-3-phenylpropanoic [(6-methoxy-3-oxo-3H-benzopyran-1-yl)methyl carbonic]anhydride

N-[(6-methoxy-3-oxo-3H-benzopyran-1-yl)methyloxycarbonyl]-L-phenylalanine methyl ester

Refernces

• 1、 McCarron, Stephen T.,Feliciano, Mariel,Johnson, Jeffreys N.,Chambers, James J.. "Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles". . p. 2395 - 2398. Retrieved 2013/05/21.
• 2、 Suzuki, Akinobu Z.,Watanabe, Takayoshi,Kawamoto, Mika,Nishiyama, Keiko,Yamashita, Hirotaka,Ishii, Megumi,Iwamura, Michiko,Furuta, Toshiaki. "Coumarin-4-ylmethoxycarbonyls as Phototriggers for Alcohols and Phenols". . p. 4867 - 4870. Retrieved 2007/10/03.