Benzenepropanoic acid, 2-thienyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 2-thienyl ester
• CAS No.: 725249-88-7
• Molecular Formula: C13H12O2S
• Molecular Weight: 232.303
• Mol file: 725249-88-7.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, 2-thienyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, 2-thienyl ester

There total 1 articles about Benzenepropanoic acid, 2-thienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-Phenylpropionic acid (501-52-0) + di-2-thienyl carbonate (725249-83-2) → 2-thienyl 3-phenylpropionate (725249-88-7)

Guidance literature:

With dmap; In diethyl ether; at 20 ℃;

DOI:10.1246/cl.2004.552

Reference yield: 100.0%

trimethyl(3-phenylpropoxy)silane (14629-60-8) + 2-thienyl 3-phenylpropionate (725249-88-7) → 3-phenylpropionic acid 3-phenylpropyl ester (60045-27-4)

Guidance literature:

With hafnium(IV) trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1246/cl.2005.190

Reference yield: 94.0%

3-Phenyl-1-propanol (122-97-4) + 2-thienyl 3-phenylpropionate (725249-88-7) → 3-phenylpropionic acid 3-phenylpropyl ester (60045-27-4)

Guidance literature:

With bromine; In dichloromethane; at 20 ℃; for 2h; Further Variations:; Reagents; Solvents; Product distribution;

DOI:10.1246/cl.2004.968

upstream raw materials:

3-Phenylpropionic acid

di-2-thienyl carbonate

Downstream raw materials:

3-phenylpropionic acid 3-phenylpropyl ester

Refernces

• 1、 Mukaiyama, Teruaki,Oohashi, Yoshiaki,Fukumoto, Kentarou. "A new method for the esterification of carboxylic acids with various alcohols by using di-2-thienyl carbonate, a new coupling reagent". . p. 552 - 553. Retrieved 2007/10/03.