7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Base Information

Chemical Name:7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one
CAS No.:144603-74-7
Molecular Formula:C15H8 Cl2 F N O2
Molecular Weight:324.1339
Hs Code.:
DSSTox Substance ID:DTXSID90932361
Wikidata:Q82908058

Synonyms:DTXSID90932361;7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one;144603-74-7

Suppliers and Price of 7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Chemical Property:

Vapor Pressure:2.82E-10mmHg at 25°C
Boiling Point:503.8°Cat760mmHg
Flash Point:258.5°C
Density:1.54g/cm³
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:322.9916120
Heavy Atom Count:21
Complexity:455

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2(C(=O)C3=C(C(=C(C=C3)Cl)Cl)NC2=O)F
Isomeric SMILES:C1=CC=C(C=C1)[C@]2(C(=O)C3=C(C(=C(C=C3)Cl)Cl)NC2=O)F

Technology Process of 7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

There total 4 articles about 7,8-Dichloro-3-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 144603-46-3
3,7,8-Trichloro-3-phenyl-1H-quinoline-2,4-dione

: 144603-74-7
7,8-Dichloro-3-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In acetonitrile; for 6h; Heating;
DOI:10.1007/BF00816857

Reference yield:

: 608-27-5
2,3-dichloroaniline

: 144603-74-7
7,8-Dichloro-3-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 4 h / 280 °C

2: 79 percent / SO₂Cl₂ / dioxane / 0.17 h / 40 - 60 °C

3: 67 percent / KF, 18-crown-6 / acetonitrile / 6 h / Heating

With potassium fluoride; sulfuryl dichloride; 18-crown-6 ether; In 1,4-dioxane; acetonitrile;
DOI:10.1007/BF00816857

Reference yield:

: 144603-11-2
RJC 03105

: 144603-74-7
7,8-Dichloro-3-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / SO₂Cl₂ / dioxane / 0.17 h / 40 - 60 °C

2: 67 percent / KF, 18-crown-6 / acetonitrile / 6 h / Heating

With potassium fluoride; sulfuryl dichloride; 18-crown-6 ether; In 1,4-dioxane; acetonitrile;
DOI:10.1007/BF00816857