3-AMino-4-broMobenzonitrile

Base Information

• Chemical Name: 3-AMino-4-broMobenzonitrile
• CAS No.: 72635-78-0
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2926909090
• Mol file: 72635-78-0.mol

Synonyms:4-Amino-3-bromobenzonitrile;3-Amino-4-brom-benzonitril;3-amino-4-bromo-benzonitrile;

Chemical Property of 3-AMino-4-broMobenzonitrile

Chemical Property:

• Melting Point: 99 °C
• Boiling Point: 315.2±22.0 °C(Predicted)
• PKA: 0.73±0.10(Predicted)
• PSA: 49.81000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: 2.48418
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98.5% ^*data from raw suppliers

3-Amino-4-bromobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMino-4-broMobenzonitrile

There total 3 articles about 3-AMino-4-broMobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-cyanoaniline (2237-30-1) → 5-amino-2-bromo-benzonitrile (72115-09-4) + 3-amino-4-bromobenzonitrile (72635-78-0) + 3-amino-2-bromobenzonitrile (1166988-09-5)

Guidance literature:

With N-Bromosuccinimide; In 1,4-dioxane; at 20 ℃;

DOI:10.1055/s-0028-1088016

Reference yield:

4-bromo-3-nitrobenzonitrile (89642-49-9) → 3-amino-4-bromobenzonitrile (72635-78-0)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

Reference yield:

→ 3-amino-4-bromobenzonitrile (72635-78-0)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 20 ℃;

upstream raw materials:

4-bromo-3-nitrobenzonitrile

m-cyanoaniline

Downstream raw materials:

4‐bromo‐3‐chlorobenzonitrile

2-[1-(6-cyano-1-methanesulfonyl-1H-indol-2-yl)-1-methylethyl]-4-methoxy-benzoic acid methyl ester

N-(2-bromo-5-cyanophenyl)methanesulfonamide

3-amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Refernces

• 1、 -. "SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C". Paragraph 0727 - 0729. . Retrieved 2014/09/29.