1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one

Base Information

• Chemical Name: 1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one
• CAS No.: 7294-92-0
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• DSSTox Substance ID: DTXSID40575227
• Nikkaji Number: J1.026.012D
• Wikidata: Q82464531

Synonyms:7294-92-0;DTXSID40575227;1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one

Chemical Property of 1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C(=O)CC2=CC=CC=C2)O

Technology Process of 1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one

There total 8 articles about 1-(2-Hydroxy-3-methylphenyl)-2-phenylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-hydroxy-8-methyl-3-phenyl-2H-chromen-2-one (64556-48-5) → 1-(2-hydroxy-3-methylphenyl)-2-phenylethanone (7294-92-0)

Guidance literature:

With sodium hydroxide; In water; at 140 ℃; for 0.166667h; Temperature; Sealed tube; Microwave irradiation; Green chemistry;

DOI:10.1248/cpb.c13-00604

Reference yield: 15.0%

2-methylphenyl phenylacetate (2491-29-4) → 1-(2-hydroxy-3-methylphenyl)-2-phenylethanone (7294-92-0) + 1-(4-hydroxy-3-methylphenyl)-2-phenylethan-1-one (7354-81-6)

Guidance literature:

With aluminum oxide; methanesulfonic acid; at 160 ℃; for 0.166667h;

Reference yield: 12.0%

phenylacetic acid (103-82-2) + ortho-cresol (95-48-7,77504-84-8) → 1-(2-hydroxy-3-methylphenyl)-2-phenylethanone (7294-92-0) + 1-(4-hydroxy-3-methylphenyl)-2-phenylethan-1-one (7354-81-6)

Guidance literature:

With aluminum oxide; methanesulfonic acid; at 140 ℃; for 0.0833333h;

upstream raw materials:

2-methylphenyl phenylacetate

phenylacetic acid

ortho-cresol

4-hydroxy-8-methyl-3-phenyl-2H-chromen-2-one

Downstream raw materials:

3-methyl-bibenzyl-2-ol

2-(4-oxo-2,3-diphenyl-4H-chromen-8-yl)acetic acid

2-(4-oxo-2,3-diphenyl-4H-chromen-8-yl)acetonitrile

8-Bromomethyl-2,3-diphenyl-chromen-4-one

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