(6beta)-6,17-dihydroxy-3,11,20-trioxopregn-4-en-21-yl acetate

Base Information

• Chemical Name: (6beta)-6,17-dihydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
• CAS No.: 13096-52-1
• Molecular Formula: C₂₃H₃₀O₇
• Molecular Weight: 418.487
• Mol file: 13096-52-1.mol

Synonyms:Corticosterone,11-dehydro-6b,17-dihydroxy-,21-acetate (6CI); NSC 15477

Chemical Property of (6beta)-6,17-dihydroxy-3,11,20-trioxopregn-4-en-21-yl acetate

Chemical Property:

• Vapor Pressure: 5.26E-18mmHg at 25°C
• Boiling Point: 620.7°Cat760mmHg
• Flash Point: 213.2°C
• Density: 1.32g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6beta)-6,17-dihydroxy-3,11,20-trioxopregn-4-en-21-yl acetate

There total 10 articles about (6beta)-6,17-dihydroxy-3,11,20-trioxopregn-4-en-21-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cortisone acetate (50-04-4) → 21-acetoxy-6β,17-dihydroxy-pregn-4-ene-3,11,20-trione (13096-52-1)

Guidance literature:

Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid

2: peroxybenzoic acid; chloroform

3: HClO₄; aqueous acetone / Edukt 1: ist ein Stereoisomeren-Gemisch

4: pyridine

5: HCl; CHCl₃

6: aqueous methanol.KOH

7: pyridine

With pyridine; hydrogenchloride; potassium hydroxide; perchloric acid; Perbenzoic acid; chloroform; toluene-4-sulfonic acid; acetone;

DOI:10.1021/ja01649a005

Reference yield:

21-acetoxy-5,6β,17-trihydroxy-5α-pregnane-3,11,20-trione (96263-46-6) → 21-acetoxy-6β,17-dihydroxy-pregn-4-ene-3,11,20-trione (13096-52-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: HCl; CHCl₃

3: aqueous methanol.KOH

4: pyridine

With pyridine; hydrogenchloride; potassium hydroxide; chloroform;

DOI:10.1021/ja01649a005

Reference yield:

6β,21-diacetoxy-17-hydroxy-pregn-4-ene-3,11,20-trione (98422-60-7) → 21-acetoxy-6β,17-dihydroxy-pregn-4-ene-3,11,20-trione (13096-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous methanol.KOH

2: pyridine

With pyridine; potassium hydroxide;

DOI:10.1021/ja01649a005

upstream raw materials:

6β,17,21-trihydroxypregn-4-ene-3,11,20-trione

acetic anhydride

Cortisone acetate

21-acetoxy-5,6β,17-trihydroxy-5α-pregnane-3,11,20-trione