1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one

Base Information

Chemical Name:1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one
CAS No.:73030-39-4
Molecular Formula:C₁₅H₁₆N₂O
Molecular Weight:240.305
Hs Code.:
NSC Number:125861
DSSTox Substance ID:DTXSID50298758
Nikkaji Number:J1.989.844J
ChEMBL ID:CHEMBL34449

Synonyms:73030-39-4;1,2,3,4,12,12b-hexahydroindolo[2,3-a]quinolizin-7(6h)-one;Indolo[2,3-a]quinolizin-7(6H)-one, 1,2,3,4,12,12b-hexahydro-;2,3,4,6,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-7-one;CHEMBL34449;DTXSID50298758;NSC125861;NSC-125861;PD042743;1,3,4,6,12,12B-hexahydroindolo[2,3-a]quinolizin-7(2H)-one

Suppliers and Price of 1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one

Chemical Property:

Vapor Pressure:8.01E-08mmHg at 25°C
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:240.126263138
Heavy Atom Count:18
Complexity:356

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN2CC(=O)C3=C(C2C1)NC4=CC=CC=C43

Technology Process of 1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one

There total 7 articles about 1,2,3,4,12,12b-Hexahydroindolo[2,3-a]quinolizin-7(6h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 692782-24-4
[2-(1H-indol-2-yl)-piperidin-1-yl]-acetic acid methyl ester

: 73030-39-4
7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine

Guidance literature:: With methanesulfonic acid; at 55 ℃;
DOI:10.1016/j.bmcl.2004.01.028

Reference yield: 78.0%

: N-[2-(2-indolyl)-1-piperidinylacetyl]-N,N-dimethylamine

: 73030-39-4
7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine

Guidance literature:: With trichlorophosphate; for 0.5h; Reflux; Inert atmosphere;
DOI:10.1002/jhet.3251

Reference yield:

: 1122-62-9
2-acetylpyridine

: 73030-39-4
7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol

2: polyphosphoric acid / 130 °C

3: 82 percent / H₂; acetic acid / PtO₂ / 2585.74 Torr

4: 100 percent / Na₂CO₃; n-Bu₄NI

5: 79 percent / methanesulfonic acid / 55 °C

With PPA; methanesulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; acetic acid; platinum(IV) oxide; In ethanol;
DOI:10.1016/j.bmcl.2004.01.028