(1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
CAS No.:73187-30-1
Molecular Formula:C₁₄H₁₇N₃O
Molecular Weight:243.308
Hs Code.:2933990090
UNII:RTJ6P5MVP9
DSSTox Substance ID:DTXSID80398896
Wikidata:Q72483165
Pharos Ligand ID:9HDASYNAA1RX
ChEMBL ID:CHEMBL129199
Mol file:73187-30-1.mol

Synonyms:(1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone;73187-30-1;1H-indol-2-yl-(4-methylpiperazin-1-yl)methanone;CHEMBL129199;2-(4-methylpiperazine-1-carbonyl)-1H-indole;1H-indol-2-yl(4-methylpiperazin-1-yl)methanone;(1H-Indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone;INDOL-2-YL 4-METHYLPIPERAZINYL KETONE;RTJ6P5MVP9;MLS001185451;SCHEMBL604932;DTXSID80398896;YHFMZBHLJMFAID-UHFFFAOYSA-N;HMS2826A09;AMY10455;BDBM50133020;MFCD03839454;STK175445;AKOS005410425;MS-10092;SMR000502554;CS-0322521;FT-0719566;L10036;1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone;indol-2-yl 4-methylpiperazinyl ketone, AldrichCPR;Methanone, 1H-indol-2-yl(4-methyl-1-piperazinyl)-;Methanone,1H-indol-2-yl(4-methyl-1-piperazinyl)-

Suppliers and Price of (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(1H-Indol-2-yl)(4-methylpiperazin-1-yl)methanone 95+%
1g
$ 614.00

Chemenu
(1H-Indol-2-yl)(4-methylpiperazin-1-yl)methanone 95%
1g
$ 580.00

American Custom Chemicals Corporation
(1H-INDOL-2-YL)(4-METHYLPIPERAZIN-1-YL)METHANONE 95.00%
5MG
$ 499.90

Alichem
(1H-Indol-2-yl)(4-methylpiperazin-1-yl)methanone
1g
$ 540.00

Total 13 raw suppliers

Chemical Property of (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone

Chemical Property:

Melting Point:175-176℃
PSA：39.34000
Density:1.228
LogP:1.43130
Storage Temp.:2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:243.137162174
Heavy Atom Count:18
Complexity:312

Purity/Quality:

97% ^*data from raw suppliers

(1H-Indol-2-yl)(4-methylpiperazin-1-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2

Technology Process of (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone

There total 2 articles about (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 109-01-3
1-methyl-piperazine

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 73187-30-1
(1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Indole-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 0.166667h;

1-methyl-piperazine; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1021/jm0341047

Reference yield:

: 73187-30-1
(1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone

Guidance literature:: Indol-2-carbonylchlorid, 1-Methylpiperazin;

Reference yield:

: 73187-30-1
(1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone

: 1-benzenesulfonyl-2-(4-methylpiperazin-1-ylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 - 9 h / Heating / reflux

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 10 - 25 °C

2.2: 1 h / 10 - 25 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);