2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)-

Base Information

Chemical Name:2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)-
CAS No.:732298-14-5
Molecular Formula:C43H36O6
Molecular Weight:648.755
Hs Code.:

Synonyms:

Suppliers and Price of 2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)-

There total 8 articles about 2H-1-Benzopyran-3(4H)-one, 2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 87292-50-0
(-)-(2S,3R)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]chroman-3-ol

: 732298-14-5
(-)-(2S)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]chroman-3-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2.58h;

Reference yield:

: 5447-02-9
3,4-dibenzyloxybenzaldehyde

: 732298-14-5
(-)-(2S)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]chroman-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

2.1: 7.9 g / DIBAL / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

3.1: 47.3 percent / silica gel supported H₂SO₄ / CH₂Cl₂ / 20 °C

4.1: imidazole / dimethylformamide / 20 °C

5.1: AD-mixβ; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C

6.1: 2.1 g / TBAF / tetrahydrofuran / 4 h / 20 °C

7.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C

7.2: 73 percent / K₂CO₃ / methanol; 1,2-dimethoxy-ethane / 20 °C

8.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; methanesulfonamide; sulfuric acid; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; silica gel; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; 1,4-bis(9-O-dihydroquinidine)phthalazine; orthoformic acid triethyl ester; In tetrahydrofuran; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Friedel-Craft alkylation / 5.1: Sharpless asymmetric dihydroxylation / 8.1: Dess-Martin oxidation;
DOI:10.1016/j.bmc.2004.04.033

Reference yield:

: 63604-98-8
1,3-dibenzylphloroglucinol

: 732298-14-5
(-)-(2S)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]chroman-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 47.3 percent / silica gel supported H₂SO₄ / CH₂Cl₂ / 20 °C

2.1: imidazole / dimethylformamide / 20 °C

3.1: AD-mixβ; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C

4.1: 2.1 g / TBAF / tetrahydrofuran / 4 h / 20 °C

5.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C

5.2: 73 percent / K₂CO₃ / methanol; 1,2-dimethoxy-ethane / 20 °C

6.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; methanesulfonamide; sulfuric acid; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; silica gel; Dess-Martin periodane; 1,4-bis(9-O-dihydroquinidine)phthalazine; orthoformic acid triethyl ester; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Friedel-Craft alkylation / 3.1: Sharpless asymmetric dihydroxylation / 6.1: Dess-Martin oxidation;
DOI:10.1016/j.bmc.2004.04.033