(RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one

Base Information

Chemical Name:(RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one
CAS No.:73422-75-0
Molecular Formula:C18H19NO3
Molecular Weight:297.354
Hs Code.:
DSSTox Substance ID:DTXSID60440120

Synonyms:(RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one;73422-75-0;SCHEMBL3365700;DTXSID60440120;XCPPOMFQMGXNTO-UHFFFAOYSA-N

Suppliers and Price of (RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:297.13649347
Heavy Atom Count:22
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CN(C1=O)C2=CC=C(C=C2)OCC3=CC=CC=C3)CO

Technology Process of (RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one

There total 6 articles about (RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: 133748-39-7
methyl 1-(4-benzyloxyphenyl)-5-oxo-3-pyrrolidinecarboxylate

: 73422-75-0
1-(4-Benzyloxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; Heating;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 73422-75-0
1-(4-Benzyloxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: Multi-step reaction with 4 steps

1: 93.5 percent / Heating

2: 94.7 percent / conc. H₂SO₄ / CH₂Cl₂ / 14 h / Heating

3: 96 percent / K₂CO₃ / dimethylformamide / 80 °C

4: 94.5 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

With methanol; sodium tetrahydroborate; sulfuric acid; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 39629-88-4
1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic acid

: 73422-75-0
1-(4-Benzyloxyphenyl)-4-hydroxymethyl-2-pyrrolidone

Guidance literature:: Multi-step reaction with 3 steps

1: 94.7 percent / conc. H₂SO₄ / CH₂Cl₂ / 14 h / Heating

2: 96 percent / K₂CO₃ / dimethylformamide / 80 °C

3: 94.5 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

With methanol; sodium tetrahydroborate; sulfuric acid; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9