2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Base Information

Chemical Name:2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole
CAS No.:73445-45-1
Molecular Formula:C23H19FN2O2
Molecular Weight:374.40800
Hs Code.:
DSSTox Substance ID:DTXSID70386404
Nikkaji Number:J510.124G

Synonyms:2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole;73445-45-1;Oprea1_090290;Oprea1_662069;SCHEMBL11082212;DTXSID70386404;1H-Imidazole, 2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-;STK758129;AKOS000583228;EU-0070769;SR-01000426245;SR-01000426245-1

Suppliers and Price of 2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Chemical Property:

PSA：47.14000
LogP:5.56700
XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:374.14305602
Heavy Atom Count:28
Complexity:469

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(C=C3)F)C4=CC=C(C=C4)OC

Technology Process of 2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

There total 4 articles about 2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1-benzyl-2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

: 73445-45-1
2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Guidance literature:: With potassium tert-butylate; oxygen; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 0.166667h;
DOI:10.1021/jo501664p

Reference yield: 89.0%

: 459-57-4
4-fluorobenzaldehyde

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 73445-45-1
2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Guidance literature:: With ammonium acetate; at 130 ℃; for 1.33333h; Neat (no solvent);
DOI:10.1002/cjoc.201090129

Reference yield:

: 1-benzyl-2-(4-fluorophenyl)-4,5-diiodo-1H-imidazole

: 73445-45-1
2-(4-fluorophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 80 °C / Schlenk technique; Inert atmosphere

2: potassium tert-butylate; oxygen / tetrahydrofuran; dimethyl sulfoxide / 0.17 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; oxygen; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jo501664p