2,6-Bis(diphenylhydroxymethyl)-piperidine

Base Information

• Chemical Name: 2,6-Bis(diphenylhydroxymethyl)-piperidine
• CAS No.: 58451-85-7
• Molecular Formula: C31H31NO2
• Molecular Weight: 449.63
• DSSTox Substance ID: DTXSID50974000
• Nikkaji Number: J77.393J
• Mol file: 58451-85-7.mol

Synonyms:58451-85-7;2,6-Bis(diphenylhydroxymethyl)-piperidine;2,6-Bis-(dwufenylohydroksymetylo)piperydyna [Polish];2,6-Bis-(dwufenylohydroksymetylo)piperydyna;2,6-Piperidinedimethanol, alpha,alpha,alpha',alpha'-tetraphenyl-;DTXSID50974000;(Piperidine-2,6-diyl)bis(diphenylmethanol);ethyl1-tert-butyl-5-cyano-1H-pyrazole-4-carboxylate

Chemical Property of 2,6-Bis(diphenylhydroxymethyl)-piperidine

Chemical Property:

• Vapor Pressure: 3.06E-17mmHg at 25°C
• Refractive Index: 1.6310 (estimate)
• Boiling Point: 639.7°Cat760mmHg
• PKA: 13.16±0.29(Predicted)
• Flash Point: 107.5°C
• PSA: 52.49000
• Density: 1.176g/cm³
• LogP: 5.69810
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 449.235479232
• Heavy Atom Count: 34
• Complexity: 523

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(NC(C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O

Technology Process of 2,6-Bis(diphenylhydroxymethyl)-piperidine

There total 1 articles about 2,6-Bis(diphenylhydroxymethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-bis-(1-hydroxy-1,1-diphenyl-methyl) pyridine (58451-82-4) → cis-2,6-bis(diphenylhydroxymethyl)piperidine (58451-85-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; at 80 ℃; for 24h; under 2625.26 Torr;

DOI:10.1016/j.ica.2014.02.007

Reference yield: 85.0%

cis-2,6-bis(diphenylhydroxymethyl)piperidine (58451-85-7) + vanadium(V) oxytriethoxide (1686-22-2) → {cis-2,6-bis[1,1-diphenylmethanolato]piperid-2,6-diyl}(ethanolato)oxidovanadium(V)

Guidance literature:

at 25 ℃;

DOI:10.1016/j.tet.2014.05.011

Reference yield:

cis-2,6-bis(diphenylhydroxymethyl)piperidine (58451-85-7) + V(5+)*O(2-)*3C2H5O(1-) → V(5+)*C31H29NO2(2-)*C2H5O(1-)*O(2-)

Guidance literature:

In ethanol; at 25 ℃;

DOI:10.1016/j.tet.2014.05.011

upstream raw materials:

2,6-bis-(1-hydroxy-1,1-diphenyl-methyl) pyridine