1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one

Base Information

Chemical Name:1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one
CAS No.:73691-14-2
Molecular Formula:C22H27NO4
Molecular Weight:369.461
Hs Code.:
DSSTox Substance ID:DTXSID30527255

Synonyms:73691-14-2;1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one;DTXSID30527255

Suppliers and Price of 1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:369.19400834
Heavy Atom Count:27
Complexity:465

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1CCC(=O)N1CC(C2=CC=CC=C2)C3=CC(=C(C=C3)OC)OC

Technology Process of 1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one

There total 1 articles about 1-[2-(3,4-Dimethoxyphenyl)-2-phenylethyl]-5-ethoxypyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36756-35-1
2-(3,4-dimethoxyphenyl)-2-phenylethylamine

: 73691-14-2
1-<2-(3,4-dimethoxyphenyl)-2-phenylethyl>-5-ethoxy-4,5-dihydro-2(3H)-pyrrolone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) THF, r.t., 1 h, 2) 175 deg C, 4 h

2: 15.8 g / NaBH₄, CH₃SO₃H / 1) -10 - 0 deg C, 5 h, 2) r.t., 16 h

With sodium tetrahydroborate; methanesulfonic acid;
DOI:10.1021/jo00173a053

Reference yield: 55.0%

: 73691-14-2
1-<2-(3,4-dimethoxyphenyl)-2-phenylethyl>-5-ethoxy-4,5-dihydro-2(3H)-pyrrolone

: 87519-60-6
1,5,6,10bα-tetrahydro-8,9-dimethoxy-6β-phenylpyrrolo<2,1-a>isoquinolin-3(2H)-one

: 73691-18-6
1,5,6,10bα-tetrahydro-8,9-dimethoxy-6α-phenylpyrrolo<2,1-a>isoquinolin-3(2H)-one

Guidance literature:: With hydrogenchloride; In ethanol; for 0.5h; Yield given; Heating;
DOI:10.1021/jo00173a053

Reference yield:

: 73691-14-2
1-<2-(3,4-dimethoxyphenyl)-2-phenylethyl>-5-ethoxy-4,5-dihydro-2(3H)-pyrrolone

: 87519-94-6
(6R,10bS)-8,9-Dimethoxy-6-phenyl-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: ethereal HCl / ethanol / 0.5 h / Heating

2: 1) BH₃, 2) 12.0M HCl / 1) THF, reflux, 1 h, 2) THF, water, 0 deg C, 2h

With hydrogenchloride; borane; In ethanol;
DOI:10.1021/jo00173a053