Elamipretide

Base Information

• Chemical Name: Elamipretide
• CAS No.: 736992-21-5
• Deprecated CAS: 1354575-91-9
• Molecular Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: 639.798
• UNII: 87GWG91S09
• ChEMBL ID: CHEMBL3833370
• DSSTox Substance ID: DTXSID50471988
• Metabolomics Workbench ID: 153050
• NCI Thesaurus Code: C171874
• Wikidata: Q27269822
• Mol file: 736992-21-5.mol

Synonyms:Arg-Dmt-Lys-Phe-NH2;arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide;bendavia;D-Arg-Dmt-Lys-Phe-NH2;elamipretide;MTP-131;SS-31 peptide;SS31 peptide

Chemical Property of Elamipretide

Chemical Property:

• PKA: 10.10±0.25(Predicted)
• PSA: 276.02000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 5.71560
• XLogP3: 0
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 19
• Exact Mass: 639.38566570
• Heavy Atom Count: 46
• Complexity: 991

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

Elamipretide(TFAsalt) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1CC(C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)C(CCCN=C(N)N)N)C)O
• Isomeric SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)[C@@H](CCCN=C(N)N)N)C)O
• Recent ClinicalTrials: Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)
• Recent EU Clinical Trials: A Phase 3 Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Subjects with Primary Mitochondrial Disease Resulting from Pathogenic Nuclear DNA Mutations (nPMD)

Technology Process of Elamipretide

There total 26 articles about Elamipretide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Boc-D-Arg-DMT-Lys(Boc)-Phe-NH2 → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With acetyl chloride; In isopropyl alcohol; at 0 - 40 ℃; for 1.25h; Inert atmosphere;

Reference yield:

N2-[(benzyloxy)carbonyl]-N5-[{[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl]-D-ornithyl-2,6-dimethyl-L-tyrosyl-N6-{[(2-chlorobenzyl)oxy]carbonyl}-L-lysyl-L-phenylalaninamide → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 50 ℃; for 4h;

Reference yield:

C64H73N9O13 → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 50 ℃; for 2h;

upstream raw materials:

(S)-2-amino-3-phenylpropionamide hydrochloride

H-Lys(Boc)Phe-NH₂

Z-Lys(Boc)-OH

N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 736992-21-5 D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide

Send

Send

Metric Ton KG G Pound L ML

Send

Send