D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide

Base Information

• Chemical Name: D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide
• CAS No.: 736992-21-5
• Molecular Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: 639.798
• Mol file: 736992-21-5.mol

Synonyms:L-Phenylalaninamide,D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl;

Chemical Property of D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide

Chemical Property:

• PKA: 10.10±0.25(Predicted)
• PSA: 276.02000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 5.71560

Purity/Quality:

98%+, ^*data from raw suppliers

Elamipretide(TFAsalt) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide

There total 26 articles about D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Boc-D-Arg-DMT-Lys(Boc)-Phe-NH2 → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With acetyl chloride; In isopropyl alcohol; at 0 - 40 ℃; for 1.25h; Inert atmosphere;

Reference yield:

N2-[(benzyloxy)carbonyl]-N5-[{[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl]-D-ornithyl-2,6-dimethyl-L-tyrosyl-N6-{[(2-chlorobenzyl)oxy]carbonyl}-L-lysyl-L-phenylalaninamide → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 50 ℃; for 4h;

Reference yield:

C64H73N9O13 → D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (736992-21-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 50 ℃; for 2h;

upstream raw materials:

(S)-2-amino-3-phenylpropionamide hydrochloride

H-Lys(Boc)Phe-NH₂

Z-Lys(Boc)-OH

N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide

Refernces

• 1、 -. "Methods and Compositions for Delivery of Biotin to Mitochondria". Page/Page column 22. . Retrieved 2022/03/19.
• 2、 -. "TETRAPEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME". . . Retrieved 2016/10/04.