Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester
• CAS No.: 737825-28-4
• Molecular Formula: C22H23N3O3S
• Molecular Weight: 409.509

Synonyms:

Chemical Property of Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester

There total 12 articles about Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-{5-(4-(methoxycarbonyl)benzyl)-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide (737825-27-3) → methyl 4-({2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate (737825-28-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 1h; under 1140.08 Torr;

DOI:10.1016/j.bmc.2013.02.048

Reference yield:

ethyl 2-amino-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate hydrobromide (737825-22-8) → methyl 4-({2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate (737825-28-4)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: manganese(IV) oxide / methanol; chloroform / 34 h / 20 °C / Inert atmosphere

4: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 6.5 h / 20 - 70 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1 h / 20 °C / 1140.08 Torr

With pyridine; manganese(IV) oxide; lithium borohydride; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; hydrogen; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.02.048

Reference yield:

ethyl 3-bromo-4-(4-iodophenyl)-2-oxobutanoate (737825-21-7) → methyl 4-({2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate (737825-28-4)

Guidance literature:

Multi-step reaction with 7 steps

1: ethanol / 1 h / Inert atmosphere; Reflux

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

4: manganese(IV) oxide / methanol; chloroform / 34 h / 20 °C / Inert atmosphere

5: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

6: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 6.5 h / 20 - 70 °C

7: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1 h / 20 °C / 1140.08 Torr

With pyridine; manganese(IV) oxide; lithium borohydride; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; hydrogen; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.02.048

upstream raw materials:

ethyl 4-(4-iodophenyl)-2-oxobutanoate

ethyl 3-bromo-4-(4-iodophenyl)-2-oxobutanoate

ethyl 2-amino-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate hydrobromide

ethyl 2-(acetylamino)-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate

Downstream raw materials:

methyl 4-({2-(acetylamino)-4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate hydrochloride

methyl 4-[(2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-amino)phenyl]ethyl}-1,3-thiazol-5-yl)methyl]benzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 737825-28-4 Benzoic acid, 4-[[2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-5-thiazolyl]methyl]-, methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send