(S)-α-(4'-Methylphenyl)propanol

Base Information

• Chemical Name: (S)-α-(4'-Methylphenyl)propanol
• CAS No.: 73854-03-2
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.221
• Mol file: 73854-03-2.mol

Synonyms:(1S)-1-(4-methylphenyl)propan-1-ol;(S)-1-p-Tolyl-propan-1-ol;(S)-1-(4-tolyphenyl)-1-propanol;(S)-α-(4'-methylphenyl)propanol;(S)-1-(4'-methylphenyl)-1-propanol;(S)-1-(p-methylphenyl)-1-propanol;1-(4-methylphenyl)-1-propanol;(S)-1-(4-methylphenyl)-1-propanol;(S)-1-(4-Methylphenyl)ethyl alcohol;(1S)-1-(4-methylphenyl)-1-propanol;

Chemical Property of (S)-α-(4'-Methylphenyl)propanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.43840

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-α-(4'-Methylphenyl)propanol

There total 50 articles about (S)-α-(4'-Methylphenyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethylzinc (557-20-0) + 4-methyl-benzaldehyde (104-87-0) → (S)-1-(4-methylphenyl)propan-1-ol (25574-04-3,112777-65-8,138809-38-8,73854-03-2)

Guidance literature:

(1S)-1-(9-piperidylfluoren-9-yl)ethanol; In hexane; toluene; at 0 ℃; for 4h;

DOI:10.1055/s-2000-6229

Reference yield: 99.0%

4'-methylpropiophenone (5337-93-9) → (S)-1-(4-methylphenyl)propan-1-ol (25574-04-3,112777-65-8,138809-38-8,73854-03-2)

Guidance literature:

With triiron dodecarbonyl; C₅₂H₅₈N₄P₂; hydrogen; potassium hydroxide; In methanol; at 45 ℃; for 10h; under 37503.8 Torr; enantioselective reaction;

DOI:10.1021/ja5003636

Reference yield: 99.0%

diethylzinc (557-20-0) + 4-methyl-benzaldehyde (104-87-0) → (R)-1-(4-methylphenyl)-1-propanol (25574-04-3,73854-03-2,138809-38-8,112777-65-8)

Guidance literature:

diethylzinc; With (1R,3S)-1-tert-butyl-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-1,3-dihydro-2-benzofuran-1-ol; In hexane; toluene; at 20 ℃; for 0.0833333h;

4-methyl-benzaldehyde; In hexane; toluene; at 20 ℃; for 3h; Reagent/catalyst; Temperature; enantioselective reaction; Catalytic behavior;

DOI:10.1055/s-0037-1609224

upstream raw materials:

diethylzinc

4-methyl-benzaldehyde

triethylaluminum

4-chlorobenzaldehyde

Refernces

• 1、 Yao, Chao,Wu, Piao,Huang, Yue,Chen, Yaoqi,Li, Lin,Li, Yue-Ming. "Binaphthyl-based chiral ligands: Design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes". supporting information. p. 9712 - 9725. Retrieved 2020/12/28.
• 2、 Ciprioti, Stefano Vecchio,De Angelis, Martina,Di Pietro, Federica,Iannoni, Marika,Pilloni, Luciano,Primitivo, Ludovica,Ricelli, Alessandra,Righi, Francesco,Righi, Giuliana,Sappino, Carla,Suber, Lorenza. "Linear β-amino alcohol catalyst anchored on functionalized magnetite nanoparticles for enantioselective addition of dialkylzinc to aromatic aldehydes". . p. 29688 - 29695. Retrieved 2020/10/26.