1-Piperidinecarboxylic acid, 4-methyl-, 1-[[4-[(acetylamino)methyl]phenyl]methyl]-2-[(1,1-dimethylethoxy)carbon yl]hydrazide

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Chemical Name:1-Piperidinecarboxylic acid, 4-methyl-, 1-[[4-[(acetylamino)methyl]phenyl]methyl]-2-[(1,1-dimethylethoxy)carbon yl]hydrazide
CAS No.:738615-54-8
Molecular Formula:C22H34N4O4
Molecular Weight:418.536
Hs Code.:

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-methyl-, 1-[[4-[(acetylamino)methyl]phenyl]methyl]-2-[(1,1-dimethylethoxy)carbon yl]hydrazide

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Technology Process of 1-Piperidinecarboxylic acid, 4-methyl-, 1-[[4-[(acetylamino)methyl]phenyl]methyl]-2-[(1,1-dimethylethoxy)carbon yl]hydrazide

There total 8 articles about 1-Piperidinecarboxylic acid, 4-methyl-, 1-[[4-[(acetylamino)methyl]phenyl]methyl]-2-[(1,1-dimethylethoxy)carbon yl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 626-58-4
4-methylpiperidin

: 583845-15-2
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate

: 738615-54-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-[(4-methyl-1-piperidinyl)carbonyl]-1-hydrazinecarboxylate

Guidance literature:: tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate; With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; Cooling with ether-dry ice;

at 20 ℃; for 0.5h;

4-methylpiperidin; at 20 ℃; for 1h;

Reference yield: 59.0%

: 626-58-4
4-methylpiperidin

: 32315-10-9
bis(trichloromethyl) carbonate

: 583845-15-2
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate

: 738615-54-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-[(4-methyl-1-piperidinyl)carbonyl]-1-hydrazinecarboxylate

Guidance literature:: bis(trichloromethyl) carbonate; tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

4-methylpiperidin; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 66739-89-7
4-(1,3-dioxolan-2-yl)benzonitrile

: 738615-54-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-[(4-methyl-1-piperidinyl)carbonyl]-1-hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiAlH₄ / tetrahydrofuran

2.1: 98 percent / ethanol / 5 h / Heating

3.1: 98 percent / H₂ / 10 percent Pd/C / methanol

4.1: diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 59 percent / CH₂Cl₂ / 1 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;