Chemical Property of CID 19077146
Chemical Property:
- Vapor Pressure:1.44E-07mmHg at 25°C
- Boiling Point:386.5°C at 760 mmHg
- PKA:12.70±0.20(Predicted)
- Flash Point:187.6°C
- Density:1.335g/cm3
- XLogP3:-1.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:166.06413699
- Heavy Atom Count:11
- Complexity:130
- Purity/Quality:
-
97% *data from raw suppliers
2-Deoxy-2-fluoro-L-fucose *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CC(C(C(C(C=O)F)O)O)O
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Uses
Fucose is a deoxyhexose that is present in many organisms. Fucose-containing glycans, generated by fucosyltransferase using GDP-fucose, have roles in cell signaling, cell-cell interactions, and blood properties. 2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases. Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 μM). 2-Deoxy-2-fluoro-L-fucose is a useful compound in the area of cancer treatment. as it has been used in adoptive cell therapy.
