8-(BroMoMethyl)-1,4-dioxaspiro[4.5]decane

Base Information

• Chemical Name: 8-(BroMoMethyl)-1,4-dioxaspiro[4.5]decane
• CAS No.: 74286-87-6
• Molecular Formula: C9H15BrO2
• Molecular Weight: 235.121
• Hs Code.: 2932990090
• Mol file: 74286-87-6.mol

Synonyms:8-(bromomethyl)-1,4-dioxaspiro[4.5]decane;8-bromomethyl-1.4-dioxaspiro[4.5]decane;8-(bromomethyl)-1,4-dioxaspiro[4,5]decane;

Chemical Property of 8-(BroMoMethyl)-1,4-dioxaspiro[4.5]decane

Chemical Property:

• PSA: 18.46000
• LogP: 2.31460

Purity/Quality:

97% ^*data from raw suppliers

8-(Bromomethyl)-1,4-dioxaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-(BroMoMethyl)-1,4-dioxaspiro[4.5]decane

There total 5 articles about 8-(BroMoMethyl)-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(1,4-dioxaspiro[4.5]dec-8-yl)methanol (23521-81-5,17159-82-9) → 8-(bromomethyl)-1,4-dioxaspiro<4,5>decane (74286-87-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In benzene;

DOI:10.1016/j.bmcl.2009.01.058

Reference yield:

methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate (26845-47-6) → 8-(bromomethyl)-1,4-dioxaspiro<4,5>decane (74286-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiAlH₄ / diethyl ether / 1 h / Heating

2: 69 percent / CBr₄, P(C₆H₅)3 / benzene

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In diethyl ether; benzene;

Reference yield:

4-carbomethoxycyclohexanone (6297-22-9) → 8-(bromomethyl)-1,4-dioxaspiro<4,5>decane (74286-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / p-toluenesulfonic acid / benzene / Heating

2: 90 percent / LiAlH₄ / diethyl ether / 1 h / Heating

3: 69 percent / CBr₄, P(C₆H₅)3 / benzene

With lithium aluminium tetrahydride; carbon tetrabromide; toluene-4-sulfonic acid; triphenylphosphine; In diethyl ether; benzene;

upstream raw materials:

(1,4-dioxaspiro[4.5]dec-8-yl)methanol

methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

4-carbomethoxycyclohexanone

ethyl 4-oxocyclohexane-1-carboxylate

Downstream raw materials:

8-(phenylthiomethyl)-1,4-dioxaspiro<4,5>decane

4-(phenylthiomethyl)cyclohexanone

1-(1.4-Dioxaspiro[4.5]dec-8-ylmethyl)-3-(2-methoxyphenyl)pyrrolidine

4-(bromomethyl)cyclohexanone