5-(Benzyloxy)pyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-(Benzyloxy)pyridine-2-carboxylic acid
• CAS No.: 74386-55-3
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• European Community (EC) Number: 839-511-6
• ChEMBL ID: CHEMBL166172
• DSSTox Substance ID: DTXSID00593285
• Nikkaji Number: J464.189B
• Wikidata: Q82487733
• Mol file: 74386-55-3.mol

Synonyms:74386-55-3;5-(benzyloxy)pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(phenylmethoxy)-;5-(benzyloxy)picolinic acid;5-phenylmethoxypyridine-2-carboxylic acid;CHEMBL166172;5-Benzyloxypyridine-2-carboxylic acid;SCHEMBL227231;DTXSID00593285;FQSOASDQLNSXJQ-UHFFFAOYSA-N;BDBM50000431;AKOS018352470;5-(benzyloxy)pyridine-2-carboxylicacid;5-Benzyloxy-pyridine-2-carboxylic acid;DA-38467;CS-0235440;EN300-156805;G59377;A1-27904;Z1344008301

Chemical Property of 5-(Benzyloxy)pyridine-2-carboxylic acid

Chemical Property:

• PSA: 59.42000
• LogP: 2.35880
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

99% ^*data from raw suppliers

5-(Benzyloxy)pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CN=C(C=C2)C(=O)O

Technology Process of 5-(Benzyloxy)pyridine-2-carboxylic acid

There total 5 articles about 5-(Benzyloxy)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-benzyloxy-2-pyridinecarboxylic acid methyl ester (74386-59-7) → 5-phenylmethoxypyridin-2-carboxylic acid (74386-55-3)

Guidance literature:

5-benzyloxy-2-pyridinecarboxylic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 60 ℃;

With hydrogenchloride; In water; at 20 ℃;

Reference yield:

5-benzyloxypyridin-2-carbaldehyde (59781-08-7) → 5-phenylmethoxypyridin-2-carboxylic acid (74386-55-3)

Guidance literature:

With sodium chlorite; aminosulfonic acid; water; In acetone; at 0 - 20 ℃; for 6h;

Reference yield:

5-benzyloxy-2-methyl-pyridine (63793-98-6) → 5-phenylmethoxypyridin-2-carboxylic acid (74386-55-3)

Guidance literature:

With pyridine; selenium oxide; for 24h;

upstream raw materials:

5-benzyloxypyridin-2-carbaldehyde

5-benzyloxy-2-methyl-pyridine

5-benzyloxy-2-pyridinecarboxylic acid methyl ester

Downstream raw materials:

5-(benzyloxy)-N-{4-[2-(hydroxyamino)-2-oxoethyl]-4-piperidinyl}-2-pyridinecarboxamide trifluoroacetate

5-benzyloxypyridine-2-carboxylic acid N-methoxy-N-methylamide

C₁₅H₁₆N₂O₂

2-(azetidin-1-ylcarbonyl)-5-(benzyloxy)pyridine

Refernces

• 1、 -. "1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE". Page/Page column 24-25; 41. . Retrieved 2010/11/27.
• 2、 -. "FIVE-MEMBERED HETEROCYCLIC DERIVATIVE". Page/Page column 55. . Retrieved 2010/11/08.