Hexanamide, 6-amino-N-(2-phenylethyl)-

Base Information

• Chemical Name: Hexanamide, 6-amino-N-(2-phenylethyl)-
• CAS No.: 74389-77-8
• Molecular Formula: C14H22N2O
• Molecular Weight: 234.341
• Mol file: 74389-77-8.mol

Synonyms:

Chemical Property of Hexanamide, 6-amino-N-(2-phenylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexanamide, 6-amino-N-(2-phenylethyl)-

There total 4 articles about Hexanamide, 6-amino-N-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Z-Aca-PHA (70035-19-7) → H-Aca-PHA (74389-77-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 0.666667h; Ambient temperature;

Reference yield:

(5-phenethylcarbamoyl-pentyl)carbamic acid tert-butyl ester (141381-79-5) → H-Aca-PHA (74389-77-8)

Guidance literature:

(5-phenethylcarbamoyl-pentyl)carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; water; In dichloromethane;

Reference yield:

C17H23NO6 → H-Aca-PHA (74389-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 0.67 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol;

upstream raw materials:

Z-Aca-PHA

(5-phenethylcarbamoyl-pentyl)carbamic acid tert-butyl ester

phenethylamine

Downstream raw materials:

Z-Tyr-Aca-PHA

N₁-phenethyl-hexane-1,6-diamine

6-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-hexanoic acid phenethyl-amide

Refernces

• 1、 Minarini,Budriesi,Chiarini,Melchiorre,Tumiatti. "Further investigation on methoctramine-related tetraamines: Effects of terminal N-substitution and of chain length separating the four nitrogens on M2 muscarinic receptor blocking activity". . p. 1167 - 1178. Retrieved 2007/10/02.