2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline

Base Information

• Chemical Name: 2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline
• CAS No.: 74462-23-0
• Molecular Formula: C12H12N2S
• Molecular Weight: 216.307
• DSSTox Substance ID: DTXSID40504537
• Nikkaji Number: J3.167.385B
• Wikidata: Q82359103
• Mol file: 74462-23-0.mol

Synonyms:74462-23-0;2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline;DTXSID40504537;AKOS000174252

Chemical Property of 2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.07211956
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)N)SCC2=CN=CC=C2

Technology Process of 2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline

There total 2 articles about 2-{[(Pyridin-3-yl)methyl]sulfanyl}aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-chloromethylpyridinium chloride (6959-48-4) + 2-amino-benzenethiol (137-07-5) → 2-(pyridin-3-ylmethylsulfanyl)phenylamine (74462-23-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; for 4h;

Reference yield:

2-amino-benzenethiol (137-07-5) → 2-(pyridin-3-ylmethylsulfanyl)phenylamine (74462-23-0)

Guidance literature:

2-amino-benzenethiol; With sodium isopropylate; In isopropyl alcohol; at 20 ℃;

halide RX, R=3-pyridylmethyl; In isopropyl alcohol; Reflux;

DOI:10.1248/cpb.56.1400

Reference yield: 65.0%

acetic anhydride (108-24-7) + 2-(pyridin-3-ylmethylsulfanyl)phenylamine (74462-23-0) → N-[2-(Pyridin-3-ylmethylsulfanyl)-phenyl]-acetamide (74462-32-1)

Guidance literature:

for 4h; Ambient temperature;

upstream raw materials:

3-chloromethylpyridinium chloride

2-amino-benzenethiol

Downstream raw materials:

N-[2-(Pyridin-3-ylmethylsulfanyl)-phenyl]-acetamide

2-(3-picolilsolfonil)anilina

N-[2-(Pyridin-3-ylmethanesulfonyl)-phenyl]-acetamide

3-(2-Pyrrol-1-yl-benzenesulfonylmethyl)-pyridine