Benzenesulfonic acid, 4-methyl-, 2-(aminothioxomethyl)hydrazide

Base Information

• Chemical Name: Benzenesulfonic acid, 4-methyl-, 2-(aminothioxomethyl)hydrazide
• CAS No.: 7449-47-0
• Molecular Formula: C8H11N3O2S2
• Molecular Weight: 245.326
• Mol file: 7449-47-0.mol

Synonyms:

Chemical Property of Benzenesulfonic acid, 4-methyl-, 2-(aminothioxomethyl)hydrazide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfonic acid, 4-methyl-, 2-(aminothioxomethyl)hydrazide

There total 3 articles about Benzenesulfonic acid, 4-methyl-, 2-(aminothioxomethyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

thiosemicarbazide (79-19-6) + p-toluenesulfonyl chloride (98-59-9) → N4-(4-Toluenesulfonyl)thiosemicarbazide (7449-47-0)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 48h;

DOI:10.3390/molecules22081352

Reference yield:

barium thiocyanate (2092-17-3) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N4-(4-Toluenesulfonyl)thiosemicarbazide (7449-47-0)

Guidance literature:

With sulfuric acid;

Reference yield:

→ N4-(4-Toluenesulfonyl)thiosemicarbazide (7449-47-0)

Guidance literature:

Verb./BRN= 607898/, Thiosemicarbazide, H2O, AcONa, Δ;

upstream raw materials:

barium thiocyanate

toluene-4-sulfonic acid hydrazide

thiosemicarbazide

p-toluenesulfonyl chloride

Downstream raw materials:

5-ethoxycarbonyl-4-methyl-2-[2-(p-toluenesulfonyl)-hydrazino]-thiazole

ethyl (2-[2-(p-toluenesulfonyl)-hydrazino]-thiazol-4-yl)acetate

4-methyl-2-[2-(p-toluenesulfonyl)-hydrazino]-thiazole

4-chloromethyl-2-[2-(p-toluenesulfonyl)-hydrazino]-thiazole

Refernces

• 1、 Zaharia, Valentin,Ignat, Adriana,Palibroda, Nicolae,Ngameni, Bathélémy,Kuete, Victor,Fokunang, Charles N.,Moungang, Marlyse L.,Ngadjui, Bonaventure T.. "Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity". experimental part. p. 5080 - 5085. Retrieved 2010/12/24.