2-Amino-5-methoxy-1-methylbenzimidazole

Base Information

• Chemical Name: 2-Amino-5-methoxy-1-methylbenzimidazole
• CAS No.: 1805-02-3
• Molecular Formula: C₉H₁₁N₃O
• Molecular Weight: 177.206
• Hs Code.: 2933990090
• Mol file: 1805-02-3.mol

Synonyms:Benzimidazole,2-amino-5-methoxy-1-methyl- (6CI,7CI); 5-Methoxy-1-methyl-2-aminobenzimidazole;5-Methoxy-1-methylbenzimidazole-2-amine

Chemical Property of 2-Amino-5-methoxy-1-methylbenzimidazole

Chemical Property:

• Vapor Pressure: 9.41E-06mmHg at 25°C
• Boiling Point: 372.7°Cat760mmHg
• PKA: 7.16±0.10(Predicted)
• Flash Point: 179.2°C
• PSA: 53.07000
• Density: 1.28g/cm³
• LogP: 1.74530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-methoxy-1-methylbenzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-methoxy-1-methylbenzimidazole

There total 2 articles about 2-Amino-5-methoxy-1-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-1-methyl-1H-benzo[d]imidazole (10394-39-5) → 5-methoxy-1-methyl-1H-benzoimidazol-2-ylamine (1805-02-3)

Guidance literature:

With sodium amide; xylene;

Reference yield:

N-methyl-4-methoxy-2-nitroaniline (3360-79-0) → 5-methoxy-1-methyl-1H-benzoimidazol-2-ylamine (1805-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tin; aqueous HCl / Erhitzen des Reaktionsprodukts mit wss. Ameisensaeure

2: xylene; NaNH₂

With hydrogenchloride; tin; sodium amide; xylene;

Reference yield: 80.0%

5-methoxy-1-methyl-1H-benzoimidazol-2-ylamine (1805-02-3) → (5-methoxy-1-methyl-1H-benzoimidazol-2-yl)-nitroso-amine (53114-88-8)

Guidance literature:

With phosphoric acid; sodium nitrite; In water; at -5 - 3 ℃; for 0.5h;

DOI:10.1007/BF00476539

upstream raw materials:

5-methoxy-1-methyl-1H-benzo[d]imidazole

N-methyl-4-methoxy-2-nitroaniline

Downstream raw materials:

(5-methoxy-1-methyl-1H-benzoimidazol-2-yl)-nitroso-amine