N(4), O(2')-Dimethylcytidine

Base Information

• Chemical Name: N(4), O(2')-Dimethylcytidine
• CAS No.: 13048-95-8
• Molecular Formula: C11H17 N3 O5
• Molecular Weight: 271.27
• DSSTox Substance ID: DTXSID00156571
• Nikkaji Number: J2.140.784D
• Wikidata: Q83024658
• Mol file: 13048-95-8.mol

Synonyms:N(4), O(2')-dimethylcytidine

Chemical Property of N(4), O(2')-Dimethylcytidine

Chemical Property:

• Boiling Point: 475.4°Cat760mmHg
• PKA: 13.37±0.70(Predicted)
• Flash Point: 241.3°C
• PSA: 109.33000
• Density: 1.54g/cm³
• LogP: -1.61520
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly), Water (Slightly)
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 271.11682065
• Heavy Atom Count: 19
• Complexity: 411

Purity/Quality:

97% ^*data from raw suppliers

N4-Methyl-2''-O-methyl-cytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)OC
• Isomeric SMILES: CNC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC

Technology Process of N(4), O(2')-Dimethylcytidine

There total 14 articles about N(4), O(2')-Dimethylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3',5'-di-O-acetyl-N4,2'-O-dimethylcytidine (1085342-83-1) → N4,2'-O-dimethylcytidine (13048-95-8)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2008.09.016

Reference yield: 95.0%

4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine (110588-51-7) → N4,2'-O-dimethylcytidine (13048-95-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield: 61.4%

C23H45N3O5Si2 (1613530-40-7) → N4,2'-O-dimethylcytidine (13048-95-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

upstream raw materials:

trimethylsulphonium hydroxide

2'-O-methylcytidine

4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine

1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone

Refernces

• 1、 -. "ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF". . . Retrieved 2016/06/15.
• 2、 -. "Alternative nucleic acid molecules and uses thereof". . . Retrieved 2015/11/09.