1,3-Difluoro-5-(methoxymethoxy)benzene

Base Information

• Chemical Name: 1,3-Difluoro-5-(methoxymethoxy)benzene
• CAS No.: 749230-20-4
• Molecular Formula: C8H8F2O2
• Molecular Weight: 174.147
• DSSTox Substance ID: DTXSID80710135
• Wikidata: Q82645385
• Mol file: 749230-20-4.mol

Synonyms:1,3-Difluoro-5-(methoxymethoxy)benzene;749230-20-4;Benzene, 1,3-difluoro-5-(methoxymethoxy)-;MFCD13248876;SCHEMBL8140047;DTXSID80710135;AC6738;SY233664;CS-0193626;A915188

Chemical Property of 1,3-Difluoro-5-(methoxymethoxy)benzene

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 174.04923582
• Heavy Atom Count: 12
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC(=CC(=C1)F)F

Technology Process of 1,3-Difluoro-5-(methoxymethoxy)benzene

There total 2 articles about 1,3-Difluoro-5-(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,5-difluorophenol (2713-34-0) + chloromethyl methyl ether (107-30-2) → 1,3-difluoro-5-(methoxymethoxy)benzene (749230-20-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1055/s-2004-829110

Reference yield:

bromethyl methyl ether (13057-17-5) + 3,5-difluorophenol (2713-34-0) → 1,3-difluoro-5-(methoxymethoxy)benzene (749230-20-4)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

Reference yield: 98.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1,3-difluoro-5-(methoxymethoxy)benzene (749230-20-4) → C9H8F2O3

Guidance literature:

1,3-difluoro-5-(methoxymethoxy)benzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

DOI:10.1055/s-0040-1707117

upstream raw materials:

3,5-difluorophenol

chloromethyl methyl ether

bromethyl methyl ether

Downstream raw materials:

[2,6-difluoro-4-(methoxymethoxy)phenyl]trimethylsilane

2,6-difluoro-4-hydroxybenzoic acid

4,6-difluoro-2-hydroxybenzoic acid

ethyl 2,6-difluoro-3-(methoxymethoxy)benzoate