5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine

Base Information

• Chemical Name: 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine
• CAS No.: 74959-55-0
• Molecular Formula: C14H10N4O2S
• Molecular Weight: 298.325
• ChEMBL ID: CHEMBL224892
• DSSTox Substance ID: DTXSID70414892
• Nikkaji Number: J2.846.342A
• Wikidata: Q82223963
• Mol file: 74959-55-0.mol

Synonyms:5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine;74959-55-0;CHEMBL224892;DTXSID70414892;2-(Phenylamino)-5-(4-nitrophenyl)-1,3,4-thiadiazole

Chemical Property of 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 298.05244675
• Heavy Atom Count: 21
• Complexity: 351

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=NN=C(S2)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine

There total 14 articles about 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-nitrobenzaldehdye (555-16-8) + 4-Phenyl-3-thiosemicarbazide (5351-69-9) → 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine (74959-55-0)

Guidance literature:

With thiourea; In acetonitrile; at 30 ℃; for 0.5h;

DOI:10.1002/jhet.367

Reference yield: 93.0%

4-nitrobenzaldehdye (555-16-8) + phenyl isothiocyanate (103-72-0) → 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine (74959-55-0)

Guidance literature:

phenyl isothiocyanate; With 1-butyl-3-methylimidazolium Tetrafluoroborate; hydrazine;

4-nitrobenzaldehdye; With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 30 - 40 ℃; for 0.25h; Further stages.;

DOI:10.1002/hc.20432

Reference yield: 88.0%

1-[3-(4-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.7]dodec-2-en-4-yl]-3-phenyl-thiourea (156360-54-2) → 5-(4-nitrophenyl)-N-phenyl-1,3,4-thiadiazol-2-amine (74959-55-0)

Guidance literature:

With trifluoroacetic anhydride; In benzene; for 6h; Ambient temperature;

upstream raw materials:

1-(p-nitrobenzoyl)-4-phenyl-3-thiosemicarbazide

1-[3-(4-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.7]dodec-2-en-4-yl]-3-phenyl-thiourea

phenyl isothiocyanate

4-nitro-benzoyl chloride