Cyclohexanone, 2-[(trimethylsilyl)methyl]-

Base Information

• Chemical Name: Cyclohexanone, 2-[(trimethylsilyl)methyl]-
• CAS No.: 75142-63-1
• Molecular Formula: C10H20OSi
• Molecular Weight: 184.354
• DSSTox Substance ID: DTXSID20475296
• Nikkaji Number: J1.366.768C
• Mol file: 75142-63-1.mol

Synonyms:Cyclohexanone, 2-[(trimethylsilyl)methyl]-;75142-63-1;DTXSID20475296

Chemical Property of Cyclohexanone, 2-[(trimethylsilyl)methyl]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 184.128341792
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CC1CCCCC1=O

Technology Process of Cyclohexanone, 2-[(trimethylsilyl)methyl]-

There total 10 articles about Cyclohexanone, 2-[(trimethylsilyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-<(phenylthio)trimethylsilylmethyl>cyclohexanone (82202-15-1) → 2-<(trimethylsilyl)methyl>cyclohexanone (75142-63-1)

Guidance literature:

With nickel; In acetone; for 3h;

Reference yield: 82.0%

iodo(trimethylsilyl)methane (4206-67-1) + cyclohexanone N-cyclohexylimine (10468-40-3) → 2-<(trimethylsilyl)methyl>cyclohexanone (75142-63-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.75h;

Reference yield: 80.0%

Trimethyl-(2-nitro-cyclohexylmethyl)-silane (269405-72-3) → 2-<(trimethylsilyl)methyl>cyclohexanone (75142-63-1)

Guidance literature:

Trimethyl-(2-nitro-cyclohexylmethyl)-silane; With potassium hydride; In 1,4-dioxane; at 10 ℃; for 1h;

With chloro-trimethyl-silane; In 1,4-dioxane; Further stages.; Heating;

DOI:10.1055/s-2006-950225

upstream raw materials:

iodo(trimethylsilyl)methane

cyclohexanone N-cyclohexylimine

1-(Trimethylsilyloxy)cyclohexene

trimethylsilane

Downstream raw materials:

cis-1-methyl-2-trimethylsilylmethylcyclohexan-1-ol

2-Bromo-2-trimethylsilanylmethyl-cyclohexanone

(E)-2-trimethylsilylmethylcyclohexanone oxime

(Z)-2-trimethylsilylmethylcyclohexanone oxime