4-(Chloromethyl)-1-fluoro-2-phenoxybenzene

Base Information

• Chemical Name: 4-(Chloromethyl)-1-fluoro-2-phenoxybenzene
• CAS No.: 75210-42-3
• Molecular Formula: C13H10ClFO
• Molecular Weight: 236.673
• DSSTox Substance ID: DTXSID70543914
• Wikidata: Q82420879
• Mol file: 75210-42-3.mol

Synonyms:4-(Chloromethyl)-1-fluoro-2-phenoxybenzene;75210-42-3;SCHEMBL2995636;DTXSID70543914;4-fluoro-3-phenoxyphenylmethyl chloride;(4-fluoro3-phenoxyphenyl)methyl chloride;4-fluoro--3-phenoxyphenylmethyl chloride;(4-fluoro-3-phenoxyphenyl)methyl chloride

Chemical Property of 4-(Chloromethyl)-1-fluoro-2-phenoxybenzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.35680
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 236.0404208
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=C(C=CC(=C2)CCl)F

Technology Process of 4-(Chloromethyl)-1-fluoro-2-phenoxybenzene

There total 1 articles about 4-(Chloromethyl)-1-fluoro-2-phenoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-phenoxyphenylmethanol (68359-53-5) → (4-fluoro-3-phenoxyphenyl)methyl chloride (75210-42-3)

Guidance literature:

With thionyl chloride; pyridine; In toluene;

Reference yield: 71.0%

(4-fluoro-3-phenoxyphenyl)methyl chloride (75210-42-3) + 2,2-Dimethyl-2-(4-methylphenyl)ethanol (32454-25-4) → 3-phenoxy-4-fluorobenzyl 2-(4-methylphenyl)-2-methylpropyl ether (83492-85-7)

Guidance literature:

In N,N-dimethyl-formamide; toluene;

Reference yield:

(4-fluoro-3-phenoxyphenyl)methyl chloride (75210-42-3) + 2-cyclopropyl-2-(4-chlorophenyl)ethyl ethanol → (4-fluoro-3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether

Guidance literature:

With sodium chloride; In N-methyl-acetamide; diethyl ether; hexane; water;

upstream raw materials:

4-fluoro-3-phenoxyphenylmethanol

Downstream raw materials:

4-fluoro-3-phenoxyphenylacetonitrile

3-phenoxy-4-fluorobenzyl 2-(4-methylphenyl)-2-methylpropyl ether