2-ethyl-1,3-oxazole-4-carboxylic acid(SALTDATA: FREE)

Base Information

• Chemical Name: 2-ethyl-1,3-oxazole-4-carboxylic acid(SALTDATA: FREE)
• CAS No.: 75395-42-5
• Molecular Formula: C6H7NO3
• Molecular Weight: 141.12500
• Hs Code.: 2934999090
• Mol file: 75395-42-5.mol

Synonyms:2-Ethyloxazole-4-carboxylic acid;2-Ethyl-4-oxazolecarboxylic acid;4-Oxazolecarboxylic acid,2-ethyl;

Chemical Property of 2-ethyl-1,3-oxazole-4-carboxylic acid(SALTDATA: FREE)

Chemical Property:

• Boiling Point: 274.2±13.0℃ (760 Torr)
• Flash Point: 119.6±19.8℃
• PSA: 63.33000
• Density: 1.273±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 0.93520
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-ethyl-1,3-oxazole-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethyl-1,3-oxazole-4-carboxylic acid(SALTDATA: FREE)

There total 4 articles about 2-ethyl-1,3-oxazole-4-carboxylic acid(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Ethyl-5-trimethylsilanyl-oxazole-4-carboxylic acid (88400-28-6) → 2-(ethyl)oxazole-4-carboxylic acid (75395-42-5)

Guidance literature:

With cesium fluoride; In methanol; at 80 ℃; for 14h; Yield given;

DOI:10.1016/S0040-4039(00)85905-5

Reference yield:

2-methyl-1,3-oxazol-4-carboxylic acid (23012-17-1) → 2-(ethyl)oxazole-4-carboxylic acid (75395-42-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1.) THF, -40 deg C

2: t-BuLi / tetrahydrofuran / 0.03 h / -78 °C

3: 86 percent

4: CsF / methanol / 14 h / 80 °C

With tert.-butyl lithium; cesium fluoride; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)85905-5

Reference yield:

2-Methyl-5-trimethylsilanyl-oxazole-4-carboxylic acid (88400-25-3) → 2-(ethyl)oxazole-4-carboxylic acid (75395-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuLi / tetrahydrofuran / 0.03 h / -78 °C

2: 86 percent

3: CsF / methanol / 14 h / 80 °C

With tert.-butyl lithium; cesium fluoride; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)85905-5

upstream raw materials:

2-Ethyl-5-trimethylsilanyl-oxazole-4-carboxylic acid

2-methyl-1,3-oxazol-4-carboxylic acid

2-Methyl-5-trimethylsilanyl-oxazole-4-carboxylic acid

Downstream raw materials:

1-(2-ethyloxazol-4-yl)-3-phenylurea