1-Pyrrolidinecarboxamide, N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl] oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxamide, N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl] oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)-
CAS No.:757247-81-7
Molecular Formula:C21H29ClF3N3O3Si
Molecular Weight:492.013
Hs Code.:

1-Pyrrolidinecarboxamide,
N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]
oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxamide, N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl] oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)-

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Technology Process of 1-Pyrrolidinecarboxamide, N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl] oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)-

There total 16 articles about 1-Pyrrolidinecarboxamide, N-(3-chloro-4-cyano-2-methylphenyl)-3-[[(1,1-dimethylethyl)dimethylsilyl] oxy]-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 627531-80-0
2-chloro-4-isocyanato-3-methyl-benzonitrile

: C₁₂H₂₄F₃NO₂Si

: 757247-81-7
(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]-pyrrolidine-1-carboxylic acid (3-chloro-4-cyano-2-methyl-phenyl)-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jm070312d

Reference yield:

: 627531-80-0
2-chloro-4-isocyanato-3-methyl-benzonitrile

: 757247-81-7
(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]-pyrrolidine-1-carboxylic acid (3-chloro-4-cyano-2-methyl-phenyl)-amide

Guidance literature:: C₁₃H₂₄F₃NO₄Si; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 0.25h;

2-chloro-4-isocyanato-3-methyl-benzonitrile; In dichloromethane; at -78 - 20 ℃; for 2h;

Reference yield:

: 496841-07-7
(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester

: 757247-81-7
(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]-pyrrolidine-1-carboxylic acid (3-chloro-4-cyano-2-methyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / KOH / methanol / 2.42 h / 0 °C

2: i-Pr₂NEt / DMAP / CH₂Cl₂ / 48 h / 20 °C

3: LiBHEt₃ / tetrahydrofuran / -78 - 20 °C

4: 4-methylmorpholine N-oxide / n-Pr₄NRuO₄ / acetonitrile; CH₂Cl₂ / 4 h / 20 °C

5: 51 percent / CsF / 29 h / 20 - 50 °C

6: TFA / CH₂Cl₂ / 0.5 h / 20 °C

7: 93 percent / i-Pr₂NEt / CH₂Cl₂ / -78 - 20 °C

With potassium hydroxide; lithium triethylborohydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; dmap; tetrapropylammonium perruthennate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm070312d