methyl 4-(2-(trimethylsilyl)ethynyl)benzoate

Base Information

• Chemical Name: methyl 4-(2-(trimethylsilyl)ethynyl)benzoate
• CAS No.: 75867-41-3
• Molecular Formula: C13H16O2Si
• Molecular Weight: 232.354
• Mol file: 75867-41-3.mol

Synonyms:methyl 4-trimethylsilylethynylbenzoate;4-trimethylsilylethynylbenzoic acid methyl ester;4-trimethylsilanylethynyl-benzoic acid methyl ester;

Chemical Property of methyl 4-(2-(trimethylsilyl)ethynyl)benzoate

Chemical Property:

• PSA: 26.30000
• LogP: 2.70210
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-((trimethylsilyl)ethynyl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-(2-(trimethylsilyl)ethynyl)benzoate

There total 13 articles about methyl 4-(2-(trimethylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-iodobenzoate (619-44-3) + trimethylsilylacetylene (1066-54-2) → 4-trimethylsilanylethynyl-benzoic acid methyl ester (75867-41-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 8h;

Reference yield: 98.0%

4-methoxycarbonylphenyl bromide (619-42-1) + trimethylsilylacetylene (1066-54-2) → 4-trimethylsilanylethynyl-benzoic acid methyl ester (75867-41-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 0.416667h; Microwave irradiation; Inert atmosphere;

DOI:10.3390/molecules21010016

Reference yield: 91.0%

4-ethynylbenzoic acid methyl ester (3034-86-4) + N,N-diethyl-1,1,1-trimethylsilanamine (996-50-9) → 4-trimethylsilanylethynyl-benzoic acid methyl ester (75867-41-3)

Guidance literature:

With zinc(II) chloride; In 1,4-dioxane; at 100 ℃; for 1.5h;

DOI:10.1021/ol036328p

upstream raw materials:

4-methoxycarbonylphenyl bromide

trimethylsilylacetylene

methyl 4-iodobenzoate

4-ethynylbenzoic acid methyl ester

Downstream raw materials:

methyl 4-(1-(4-hydroxyphenyl)vinyl)benzoate

4-[(E)-1-(4-Hydroxy-phenyl)-2-trimethylsilanyl-vinyl]-benzoic acid methyl ester

4-[(Z)-2-(4-Hydroxy-phenyl)-2-trimethylsilanyl-vinyl]-benzoic acid methyl ester

4-Ethynyl-benzoic acid