1-Pyrrolidinecarboxamide, N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxamide, N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-
CAS No.:762286-00-0
Molecular Formula:C27H33F3N4O3
Molecular Weight:518.579
Hs Code.:

1-Pyrrolidinecarboxamide,
N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro
methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxamide, N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

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Technology Process of 1-Pyrrolidinecarboxamide, N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)-

There total 7 articles about 1-Pyrrolidinecarboxamide, N-[(3R)-1-(2-hydroxyethyl)-3-pyrrolidinyl]-N-methyl-3-[methyl[[4'-(trifluoro methyl)[1,1'-biphenyl]-4-yl]carbonyl]amino]-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-46-8
Glycolaldehyde

: 762285-99-4
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid methyl-(R)-pyrrolidin-3-yl-amide

: 762286-00-0
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid [(R)-1-(2-hydroxy-ethyl)-pyrrolidin-3-yl]-methyl-amide

Guidance literature:: Glycolaldehyde; (S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid methyl-(R)-pyrrolidin-3-yl-amide; In methanol; for 0.166667h;

With sodium tris(acetoxy)borohydride; In methanol; for 20h;

Reference yield:

: 144043-17-4
(3R)-1-benzyl-N-methylpyrrolidin-3-amine

: 762286-00-0
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid [(R)-1-(2-hydroxy-ethyl)-pyrrolidin-3-yl]-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran

2: dimethylformamide / 100 °C

3: ammonium formate / Pd/C / ethanol / Heating

4: NaBH₃CN / methanol

5: TFA / CH₂Cl₂

6: CH₂Cl₂

With ammonium formate; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.12.036

Reference yield:

: 762285-93-8
((R)-1-benzylpyrrolidin-3-yl)-methyl-carbamic acid 4-nitrophenyl ester

: 762286-00-0
(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid [(R)-1-(2-hydroxy-ethyl)-pyrrolidin-3-yl]-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 100 °C

2: ammonium formate / Pd/C / ethanol / Heating

3: NaBH₃CN / methanol

4: TFA / CH₂Cl₂

5: CH₂Cl₂

With ammonium formate; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.12.036