4-(CYCLOHEXYLMETHOXY)ANILINE

Base Information

• Chemical Name: 4-(CYCLOHEXYLMETHOXY)ANILINE
• CAS No.: 76253-28-6
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol file: 76253-28-6.mol

Synonyms:N-(4-(cyclohexylmethoxy)phenyl)acetamide;4-Cyclohexylmethoxy-phenylamine;4-cyclohexylmethoxy-aniline;p-cyclohexylmethoxyaniline;

Chemical Property of 4-(CYCLOHEXYLMETHOXY)ANILINE

Chemical Property:

• PSA: 35.25000
• LogP: 3.80910

Purity/Quality:

98%min ^*data from raw suppliers

4-(cyclohexylmethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-(CYCLOHEXYLMETHOXY)ANILINE

There total 6 articles about 4-(CYCLOHEXYLMETHOXY)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Cyclohexylmethoxy-4-nitro-benzene (76253-40-2) → 4-(cyclohexylmethoxy)aniline (76253-28-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.30.3580

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-(cyclohexylmethoxy)aniline (76253-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.5 percent / NaH / dimethylformamide / 1 h / 0 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.3580

Reference yield:

cyclohexylmethyl alcohol (100-49-2) → 4-(cyclohexylmethoxy)aniline (76253-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.5 percent / NaH / dimethylformamide / 1 h / 0 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.3580

upstream raw materials:

1-Cyclohexylmethoxy-4-nitro-benzene

4-Fluoronitrobenzene

cyclohexylmethyl alcohol

4-acetaminophenol

Downstream raw materials:

5-(4-Cyclohexylmethoxy-benzyl)-2-imino-thiazolidin-4-one

5-(4-(cyclohexylmethoxy)benzyl)thiazolidine-2,4-dione

2-Chloro-3-(4-cyclohexylmethoxy-phenyl)-propionic acid methyl ester

Refernces

• 1、 Sohda,Mizuno,Imamiya,Sugiyama,Fujita,Kawamatsu. "Studies on antidiabetic agents. II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives". . p. 3580 - 3600. Retrieved 2007/10/02.