2,4-Dichloro-5-(chloromethyl)pyrimidine

Base Information

Chemical Name:2,4-Dichloro-5-(chloromethyl)pyrimidine
CAS No.:7627-38-5
Molecular Formula:C5H3Cl3N2
Molecular Weight:197.451
Hs Code.:2933599090
European Community (EC) Number:826-881-9
DSSTox Substance ID:DTXSID00544030
Wikidata:Q72465862
Mol file:7627-38-5.mol

Synonyms:2,4-dichloro-5-(chloromethyl)pyrimidine;7627-38-5;2,4-Dichloro-5-chloromethylpyrimidine;MFCD10697639;2,4-dichloro-5-chloromethyl-pyrimidine;Pyrimidine, 2,4-dichloro-5-(chloromethyl)-;SCHEMBL4321200;DTXSID00544030;VLOODHWTRPYFIS-UHFFFAOYSA-N;2,4-Dichlor-5-chlormethylpyrimidin;AMY10144;2,4-dichloro-5-choromethyl-pyrimidine;AKOS005073041;AB60133;HD-0720;AC-30158;SY192957;CS-0059796;EN300-84132;W12217;A865514;J-507121;Z1171220831

Suppliers and Price of 2,4-Dichloro-5-(chloromethyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2,4-Dichloro-5-(chloromethyl)pyrimidine 95%
5 g
$ 805.00

SynQuest Laboratories
2,4-Dichloro-5-(chloromethyl)pyrimidine 95%
1 g
$ 261.00

Matrix Scientific
2,4-Dichloro-5-(chloromethyl)pyrimidine >95%
5mg
$ 1290.00

Matrix Scientific
2,4-Dichloro-5-(chloromethyl)pyrimidine >95%
1g
$ 430.00

Matrix Scientific
2,4-Dichloro-5-(chloromethyl)pyrimidine >95%
500mg
$ 300.00

Crysdot
2,4-Dichloro-5-(chloromethyl)pyrimidine 95+%
1g
$ 431.00

Chemenu
2,4-Dichloro-5-(chloromethyl)pyrimidine 95%
1g
$ 403.00

Biosynth Carbosynth
2,4-Dichloro-5-(chloromethyl)pyrimidine
2 g
$ 1088.00

Biosynth Carbosynth
2,4-Dichloro-5-(chloromethyl)pyrimidine
1 g
$ 680.00

Biosynth Carbosynth
2,4-Dichloro-5-(chloromethyl)pyrimidine
250 mg
$ 290.00

Total 25 raw suppliers

Chemical Property of 2,4-Dichloro-5-(chloromethyl)pyrimidine

Chemical Property:

Melting Point:63-64°
Boiling Point:90-100 °C(Press: 0.001 Torr)
PKA:-3.42±0.29(Predicted)
PSA：25.78000
Density:1.548±0.06 g/cm3(Predicted)
LogP:2.52220
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.936181
Heavy Atom Count:10
Complexity:111

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-5-(chloromethyl)pyrimidine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=NC(=N1)Cl)Cl)CCl
Uses 2,4-Dichloro-5-(chloromethyl)pyrimidine is an intermediate; used in preparation of fused pyrimidine compounds for the treatment of cancers associated with EGFR and HER2 mutations.

Technology Process of 2,4-Dichloro-5-(chloromethyl)pyrimidine

There total 5 articles about 2,4-Dichloro-5-(chloromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 4433-40-3
5-hydroxymethyl uracil

: 7627-38-5
2,4-dichloro-5-(chloromethyl)pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 125 ℃; for 5h; Cooling with ice;

Reference yield: 77.0%

: 4433-40-3
5-(hydroxymethyl)pyrimidine-2,4-diol

: 7627-38-5
2,4-dichloro-5-(chloromethyl)pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; at 0 - 110 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00882