10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one

Base Information

• Chemical Name: 10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one
• CAS No.: 76438-44-3
• Molecular Formula: C₃₀H₂₆O₅
• Molecular Weight: 466.533
• DSSTox Substance ID: DTXSID20511067
• Wikidata: Q82369673
• Mol file: 76438-44-3.mol

Synonyms:76438-44-3;DTXSID20511067;10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one

Chemical Property of 10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one

Chemical Property:

• XLogP3: 6.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 466.17802393
• Heavy Atom Count: 35
• Complexity: 666

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)CC2(C3=CC=CC=C3C(=O)C4=CC=CC=C42)CC5=CC(=C(C=C5)O)OC)O

Technology Process of 10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one

There total 2 articles about 10,10-Bis[(4-hydroxy-3-methoxyphenyl)methyl]anthracen-9(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxymethyl-2-methoxyphenol (498-00-0) → 10,10-bis(4-hydroxy-3-methoxyphenylmethyl)-9(10H)anthracenone (76438-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 12.7 g / overnight

2: 2 g / sodium ethoxide / toluene / 1) 40 deg C, 0.5 h 2) room temperature, 1.5 h

With sodium ethanolate; In toluene;

Reference yield:

anthracen-9(10H)-one (90-44-8) + 4-chloromethyl-2-methoxyphenyl acetate (60998-35-8) → 10,10-bis(4-hydroxy-3-methoxyphenylmethyl)-9(10H)anthracenone (76438-44-3)

Guidance literature:

With sodium ethanolate; In toluene; 1) 40 deg C, 0.5 h 2) room temperature, 1.5 h;

Reference yield: 95.0%

acetic anhydride (108-24-7) + 10,10-bis(4-hydroxy-3-methoxyphenylmethyl)-9(10H)anthracenone (76438-44-3) → 10,10-bis(4-acetoxy-3-methoxyphenylmethyl)-9(10H)anthracenone (89162-48-1)

Guidance literature:

With pyridine; 1) room temperature, 20 min 2) 70 deg C, 2 h;

upstream raw materials:

anthracen-9(10H)-one

4-chloromethyl-2-methoxyphenyl acetate

4-hydroxymethyl-2-methoxyphenol

Downstream raw materials:

10,10-bis(4-acetoxy-3-methoxyphenylmethyl)-9(10H)anthracenone