N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)

Base Information

Chemical Name:N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)
CAS No.:75930-28-8
Molecular Formula:C₁₉H₂₈N₆O₇
Molecular Weight:452.467
Hs Code.:

N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)

Synonyms:

Suppliers and Price of N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.6g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name)

There total 4 articles about N-{2-[(cyclohexylcarbamoyl)(nitroso)amino]ethyl}-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-carboxamide (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 75930-35-7
N-<2-(3-cyclohexylureido)ethyl>-1,2-dideoxy-1-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-ribofuranuronamide

: 75930-28-8
N-<2-(3-cyclohexyl-1-nitrosoureido)ethyl>-1,2-dideoxy-1-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-ribofuranuronamide

Guidance literature:: With formic acid; sodium nitrite; for 0.5h;
DOI:10.1021/jm00134a011

Reference yield:

: 75930-39-1
N-(2-aminoethyl)-N-cyclohexylurea

: 75930-28-8
N-<2-(3-cyclohexyl-1-nitrosoureido)ethyl>-1,2-dideoxy-1-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-ribofuranuronamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h

2: 58 percent / NaNO₂, formic acid / 0.5 h

With formic acid; diphenylphosphoranyl azide; triethylamine; sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1021/jm00134a011

Reference yield:

: 3173-53-3
Cyclohexyl isocyanate

: 75930-28-8
N-<2-(3-cyclohexyl-1-nitrosoureido)ethyl>-1,2-dideoxy-1-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-ribofuranuronamide

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / CHCl₃ / 2 h

2: 84 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h

3: 58 percent / NaNO₂, formic acid / 0.5 h

With formic acid; diphenylphosphoranyl azide; triethylamine; sodium nitrite; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00134a011