1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-

Base Information

Chemical Name:1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-
CAS No.:767310-79-2
Molecular Formula:C14H10FN3O2
Molecular Weight:271.251
Hs Code.:
ChEMBL ID:CHEMBL188244
DSSTox Substance ID:DTXSID90461348
Wikidata:Q82285645

Synonyms:767310-79-2;5-(2-(2-Fluorophenoxy)phenyl)-1,3,4-oxadiazol-2-amine;1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-;CHEMBL188244;DTXSID90461348

Suppliers and Price of 1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:271.07570473
Heavy Atom Count:20
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NN=C(O2)N)OC3=CC=CC=C3F

Technology Process of 1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]-

There total 2 articles about 1,3,4-Oxadiazol-2-amine, 5-[2-(2-fluorophenoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 506-68-3
bromocyane

: 767310-78-1
2-(2-fluorophenoxy)benzoic acid hydrazide

: 767310-79-2
2-amino-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazole

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃;
DOI:10.1002/ardp.200300822

Reference yield:

: 395-92-6
2-(2-fluoro-phenoxy)-benzoic acid methyl ester

: 767310-79-2
2-amino-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / hydrazine hydrate / ethanol / 20 °C

2: 94 percent / NaHCO₃ / dioxane; H₂O / 20 °C

With sodium hydrogencarbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water;
DOI:10.1002/ardp.200300822