Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)

Base Information

• Chemical Name: Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)
• CAS No.: 76742-17-1
• Molecular Formula: C13H21N4O8P
• Molecular Weight: 392.306
• Mol file: 76742-17-1.mol

Synonyms:

Chemical Property of Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)

There total 5 articles about Cytidine, 5'-(hydrogen 4-morpholinylphosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

morpholinophosphonic dichloride (1498-57-3) + CYTIDINE (65-46-3) → cytidine 5'-monophosphate morpholidate (76742-17-1)

Guidance literature:

With dmap; In acetonitrile; at 0 - 50 ℃; for 2h; Reagent/catalyst; Solvent; Temperature; Time;

DOI:10.3184/174751916X14628025243831

Reference yield:

morpholine (110-91-8,99108-56-2) + [5']cytidylic acid (63-37-6) → cytidine 5'-monophosphate morpholidate (76742-17-1)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/ja01464a034

Reference yield:

morpholine (110-91-8,99108-56-2) + cytidine-5'-phosphodichloride (30784-94-2) → cytidine-5'-phosphodimorpholide (122450-01-5) + cytidine monophosphate (63-37-6,30811-80-4) + cytidine 5'-monophosphate morpholidate (76742-17-1)

Guidance literature:

With water; Yield given. Multistep reaction. Yields of byproduct given; 1.) triethyl phosphate, 5-7 deg C, 60 min, 2.) 5-7 deg C, 7 h;

DOI:10.1007/BF00764626

upstream raw materials:

morpholine

[5']cytidylic acid

cytidine-5'-phosphodichloride

cytidine monophosphate

Downstream raw materials:

citicoline

Refernces

• 1、 -. "Citicoline and synthetic method thereof". Paragraph 0014; 0016; 0018. . Retrieved 2016/10/24.