[4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone

Base Information

Chemical Name:[4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone
CAS No.:76781-15-2
Molecular Formula:C19H23N5O
Molecular Weight:337.425
Hs Code.:
DSSTox Substance ID:DTXSID40504072
Wikidata:Q82358308

Synonyms:76781-15-2;SCHEMBL11282866;DTXSID40504072;[4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone

Suppliers and Price of [4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of [4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:337.19026037
Heavy Atom Count:25
Complexity:459

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CC=C4)N

Technology Process of [4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone

There total 5 articles about [4-(4-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)piperazin-1-yl](phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1127-86-2
4-amino-2-chloro-5,6,7,8-tetrahydroquinazoline

: 13754-38-6
N-Benzoylpiperazine

: 76781-15-2
2-(4-Benzoylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: With 4-methyl-morpholine; In i-Amyl alcohol; at 180 ℃; for 5h;

Reference yield:

: 1127-85-1
2,4-dichloro-5,6,7,8-tetrahydro-quinazoline

: 76781-15-2
2-(4-Benzoylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aqu. ammonia / ethanol / 100 °C

2: 58 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C

With 4-methyl-morpholine; ammonium hydroxide; In ethanol; i-Amyl alcohol;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 76781-15-2
2-(4-Benzoylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethylate

2: phosphorous oxychloride

3: 75 percent / aqu. ammonia / ethanol / 100 °C

4: 58 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C

With 4-methyl-morpholine; ammonium hydroxide; sodium ethanolate; trichlorophosphate; In ethanol; i-Amyl alcohol;