Chemical Property of Begacestat
Chemical Property:
- Melting Point:153-155°C
- Boiling Point:355℃
- PKA:8.16±0.50(Predicted)
- Flash Point:169℃
- PSA：103.02000
- Density:1.642
- LogP:4.25320
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥15mg/mL
- XLogP3:3.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:5
- Exact Mass:390.9538321
- Heavy Atom Count:22
- Complexity:463
- Purity/Quality:
-
97% *data from raw suppliers
GSI-953 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F
- Isomeric SMILES:C1=C(SC(=C1)Cl)S(=O)(=O)N[C@H](CO)C(C(F)(F)F)C(F)(F)F
- Recent ClinicalTrials:Study Evaluating the Safety and Pharmacokinetics of a Single Dose of GSI-953
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Uses
Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.
