5-FORMYLFURAN-2-CARBONITRILE

Base Information

• Chemical Name: 5-FORMYLFURAN-2-CARBONITRILE
• CAS No.: 42061-89-2
• Molecular Formula: C6H3 N O2
• Molecular Weight: 121.095
• Hs Code.: 2932190090
• Mol file: 42061-89-2.mol

Synonyms:5-Cyano-2-furaldehyde;5-Cyano-2-furancarboxaldehyde; 5-Cyanofurfural; 5-Formyl-2-furancarbonitrile;5-Formyl-2-furonitrile

Chemical Property of 5-FORMYLFURAN-2-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.232mmHg at 25°C
• Boiling Point: 206.8°Cat760mmHg
• Flash Point: 78.9°C
• PSA: 54.00000
• Density: 1.26g/cm³
• LogP: 0.96378

Purity/Quality:

97% ^*data from raw suppliers

5-formylfuran-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FORMYLFURAN-2-CARBONITRILE

There total 8 articles about 5-FORMYLFURAN-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-hydroxymethyl-furan-2-carbonitrile (89149-70-2) → 5-cyano-2-furancarboxaldehyde (42061-89-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; sodium nitrite; In acetonitrile; at 80 ℃; under 750.075 Torr; Reagent/catalyst;

DOI:10.1002/cplu.202100062

Reference yield:

2-furancarbonitrile (617-90-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-cyano-2-furancarboxaldehyde (42061-89-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jm030025j

Reference yield:

5-hydroxymethyl-2-furfuraldehyde (67-47-0) → 5-cyano-2-furancarboxaldehyde (42061-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / aq. NH₃; I₂ / tetrahydrofuran / 1 h / 20 °C

2: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

With ammonium hydroxide; oxalyl dichloride; iodine; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;

DOI:10.1021/jm050177+

upstream raw materials:

5-hydroxymethyl-furan-2-carbonitrile

2-furancarbonitrile

N,N-dimethyl-formamide

5-hydroxymethyl-2-furfuraldehyde

Downstream raw materials:

5-hydroxymethyl-furan-2-carbonitrile