Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-

Base Information

Chemical Name:Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-
CAS No.:771476-75-6
Molecular Formula:C34H32Cl2F6N2O3
Molecular Weight:701.536
Hs Code.:

Morpholine,
4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3-
dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-

Synonyms:

Suppliers and Price of Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)-

There total 1 articles about Morpholine, 4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2,3- dihydro-2-hydroxyspiro[1H-indene-1,4'-piperidin]-1'-yl]ethyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 634909-53-8
2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethanol methanesulfonate

: spiro[(2S)-2-hydroxy]indane-1,4'-piperidine

: 771476-75-6
1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro[(2S)-2-hydroxy]indane-1,4'-piperidine

Guidance literature:: With sodium hydrogencarbonate; potassium iodide; In ISOPROPYLAMIDE; at 80 ℃; for 8h;

Reference yield: 98.0%

: 771476-75-6
1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro[(2S)-2-hydroxy]indane-1,4'-piperidine

: 598-21-0
2-Bromoacetyl bromide

: 1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro[(2S)-2-(bromoacetyl)oxy]indane-1,4'-piperidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.583333h;

Reference yield: 95.0%

: 771476-75-6
1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro[(2S)-2-hydroxy]indane-1,4'-piperidine

: 13831-31-7
Acetoxyacetyl chloride

: 1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro{(2S)-2-[(acetoxy)acetoxy]}indane-1,4'-piperidine hydrochloride

Guidance literature:: 1-(2-{(2R)-2-(3,4-dichlorophenyl)-4-[3,5-bis(trifluoromethyl)benzoyl]morpholin-2-yl}ethyl)spiro[(2S)-2-hydroxy]indane-1,4'-piperidine; Acetoxyacetyl chloride; In toluene; at 20 ℃; for 20h;

With hydrogenchloride; In 1,4-dioxane; ethanol;